Letter | Published:

Translocation 8;14 in an ataxia telangiectasia-derived cell line

Naturevolume 277pages5658 (1979) | Download Citation



THE incidence of lymphomas is 10,000 times greater than normal in patients with immunodeficiency syndromes1 and also in ataxia telangiectasia (AT), which very often involves IgA deficiency2. In addition to its other characteristic features, AT is usually associated with a defect in DNA repair3 and a translocation involving chromosome 14 in the peripheral leukocytes4. Another feature is a high prevalence of Epstein–Barr virus early antigen (EBV-EA) antibodies5 in the sera of AT patients. This is significantly higher than in normal human sera (<10%) and resembles that found in cases of Burkitt's lymphoma (BL). It is thus interesting that translocations involving chromosome 14 have been described in BL cells as well as in other lymphomatous cells6–8. This chromosome marker is also found in BL cell lines containing EB V9. It is not induced by EBV alone, however, because it is not found in EBV-positive, but non-lymphomatous cell lines, established spontaneously or by transformation of normal peripheral blood leukocytes10. We have therefore investigated whether in BL and AT some target cells of EBV infection might be genetically ‘defective’ lymphoid cells that could more easily be transformed into malignant cells (with characteristic chromosome markers) when exposed to EBV or other carcinogens. To do this we infected lymphoid cells from AT patients in vitro with EBV, and we report here a translocation t(8q; 14q+) established in one of the resulting cell lines.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Horowitz, S. D. & Hong, R. Monogr. Allergy 10, 45–46 (1977).

  2. 2

    Fraumeni, J. F. & Miller, R. W. J. natn. Cancer Inst. 38, 593–605 (1967).

  3. 3

    Paterson, M. C., Smith, B. P., Lohman, P. H. M., Anderson, A. K. & Fishman, L. Nature 260, 444–447 (1976).

  4. 4

    McCaw, B. K., Hecht, F., Harnden, D. G. & Teplitz, R. T. Proc. natn. Acad. Sci. U.S.A. 72, 2071–2075 (1975).

  5. 5

    Joncas, J., Lapointe, N., Gervais, F. & Leyritz, M. J. Immun. 119, 1857–1859 (1977).

  6. 6

    Manolov, G. & Manolova, Y. Nature 237, 33–34 (1972).

  7. 7

    Zech, L., Haglund, U., Nilsson, K. & Klein, G. Int. J. Cancer 17, 47–56 (1976).

  8. 8

    McCaw, B. K., Epstein, A. L., Kaplan, H. S. & Hecht, F. Int. J. Cancer 19, 482–486 (1977).

  9. 9

    Klein, G. New Engl. J. Med. 293, 1353–1357 (1975).

  10. 10

    Epstein, M. A. & Achong, B. G. A. Rev. Microbiol. 31, 421–445 (1977).

  11. 11

    Joncas, J. et al. Excerpta Medica Intern. Congress Series no 423 Transplantation and Clinical Immunology 9, 41–47 (1978).

  12. 12

    Dutrillaux, B. & Lejeune, J. C.r. hebd. Seanc. Acad. Sci., Paris 272, 2638 (1971)

  13. 13

    Steel, C. M., Woodward, M. A., Davidson, C., Philipson, J. & Arthur, E. Nature 270, 349–351 (1977).

  14. 14

    Cohen, M. M., Shaham, M., Degan, J., Shmueli, E. & Kohn, G. Cytogenet. Cell Genet. 15, 338–357 (1975).

  15. 15

    Webb, J., Harnden, D. G. & Harding, M. Cancer Res. 37, 997–1002 (1977).

  16. 16

    Fukuhara, A., Shirakawa, S. & Uchino, H. Nature 259, 210–211 (1976).

  17. 17

    Nilsson, K. & Ponten, J. Int. J. Cancer 15, 321–341 (1975).

Download references

Author information


  1. Laboratoire de cytogénétique, Département d'anatomie, Université de Montréal

  2. Centre de recherche pédiatrique, Hôpital Ste-Justine, Département microbiologie et de pédiatrie, Université de Montréal, Montréal, Canada, H3C 3J7

    •  & JEAN H. JONCAS


  1. Search for PIERRE JEAN in:

  2. Search for CLAUDE-LISE RICHER in:

  3. Search for MANUELA MURER-ORLANDO in:

  4. Search for DAO HUY LUU in:

  5. Search for JEAN H. JONCAS in:

About this article

Publication history



Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.