Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Mechanism of β- adrenergic relaxation of smooth muscle

Nature volume 277, pages 32–36 (1979)Cite this article

Abstract

The mechanism of β-adrenergic relaxation was investigated in isolated smooth muscle cells. β-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Dixon, W. E. J. Physiol., Lond., 30, 97–131 (1903).

    Article  CAS  Google Scholar 

  2. Hoskins, R. G. Am. J. Physiol. 29, 363–366 (1911–12).

    Google Scholar 

  3. Sutherland, E. W. & Rall, T. W. J. biol. Chem. 232, 1077–1091 (1957).

    Google Scholar 

  4. Robison, G. A., Butcher, R. W. & Sutherland, E. W. Cyclic AMP (Academic, New York, 1971).

    Google Scholar 

  5. Rubin, C. S. & Rosen, O. M. A. Rev. Biochem. 44, 831–887 (1975).

    Article  CAS  Google Scholar 

  6. Krebs, E. G. Curr. Topics Cell Regulation 5, 99–133 (1972).

    Article  CAS  Google Scholar 

  7. Nimmo, H. G. & Cohen, P. Adv. Cyclic Nucleotide Res. 8, 145–247 (1977).

    CAS  PubMed  Google Scholar 

  8. Schultz, G. & Hardman, J. G. in Regulation of Function and Growth of Eukaryotic Cells by Intracellular Cyclic Nucleotides (eds Dumont, J. E., Butcher, R. W. & Brown, B.) (Plenum, New York, 1975).

    Google Scholar 

  9. Andersson, R. et al. Adv. Cyclic Nudeotide Res. 5, 491–518 (1975).

    CAS  Google Scholar 

  10. Bohr, D. R. Pharmac. Rev. 16, 85–111 (1964).

    CAS  Google Scholar 

  11. Somlyo, A. P. & Somlyo, A. V. Pharmac. Rev. 20, 197–272 (1968).

    CAS  Google Scholar 

  12. Marshall, J. M. & Kroeger, E. A. Phil. Trans. R. Soc. Lond. B265, 135–148 (1973).

    Article  CAS  Google Scholar 

  13. Diamond, J. & Holmes, T. G. Can. J. Physiol. Pharmac. 53, 1099–1107 (1975).

    Article  CAS  Google Scholar 

  14. Kroeger, E. A. & Marshall, J. M. Am. J. Physiol. 226, 1298–1303 (1974).

    CAS  PubMed  Google Scholar 

  15. Birnbaum, J. E., Abel, P. W., Amidon, G. L. & Buchner, C. K. J. Pharmac. Exp. Ther. 194, 396–409 (1975).

    CAS  Google Scholar 

  16. Born, G. V. R. & Bülbring, E. J. Physiol., Lond. 131, 690–703 (1956).

    Article  CAS  Google Scholar 

  17. Daniel, E. E., Paton, D. M., Taylor, G. S. & Hodgson, B. J. Fedn Proc. 29, 1410–1425 (1970).

    CAS  Google Scholar 

  18. Bose, R. & Bose, D. Am. J. Physiol. 233, C8–C13 (1977).

    Article  CAS  Google Scholar 

  19. Somlyo, A. & Somlyo, A. V. Fedn Proc. 28, 1634–1648 (1969).

    CAS  Google Scholar 

  20. Schild, H. O. Br. J. Pharmac. Chemother. 31, 578–592 (1967).

    Article  CAS  Google Scholar 

  21. Bülbring, E. & Kuriyama, H. Phil. Trans. R. Soc. Lond. B265, 115–121 (1973).

    Article  Google Scholar 

  22. Kroeger, E. A., Marshall, J. M. & Bianchi, P. J. Pharmac. Exp. Ther. 193, 309–316 (1975).

    CAS  Google Scholar 

  23. Jenkinson, D. H. & Morton, I. K. M. J. Physiol., Lond. 188, 387–402 (1967).

    Article  CAS  Google Scholar 

  24. Fay, F. S. Nature 265, 553–556 (1977).

    Article  ADS  CAS  Google Scholar 

  25. Fay, F. S. & Delise, C. M. Proc. natn. Acad. Sci. U.S.A. 70, 641–645 (1973).

    Article  ADS  CAS  Google Scholar 

  26. Honeyman, T., Merriam, P. & Fay, F. S. Molec. Pharmac. 14, 86–98 (1978).

    CAS  Google Scholar 

  27. Fay, F. S. & Singer, J. J. Am. J. Physiol. 232, C144–C154 (1977).

    Article  CAS  Google Scholar 

  28. Murray, J. J., Reed, P. W. Fay, F. S. Proc. natn. Acad. Sci. U.S.A. 72, 4459–4463 (1975).

    Article  ADS  CAS  Google Scholar 

  29. Fay, F. S. & Taylor, S. R. Biophys. J. 21, 184a (1978).

    Google Scholar 

  30. Singer, J. J. & Walsh, J. V. in Excitation–Contraction Coupling in Smooth Muscle (eds Casteels, R., Godfraind, T. & Rüegg, J. C. ) (Elsevier, Amsterdam, 1977).

    Google Scholar 

  31. Walsh, J. V. & J. J. Singer, Nature (submitted).

  32. Corbin, J. D., Keely, S. L. & Park, C. R. J. biol. Chem. 250, 218–225 (1975).

    CAS  PubMed  Google Scholar 

  33. Corbin, J. D., Soderling, T. R. & Park, C. R. J. biol. Chem. 248, 1813–1821 (1973).

    CAS  PubMed  Google Scholar 

  34. Bueding, E., Bülbring, E., Gercken, G., Hawkins, J. T. & Kuriyama, H. J. Physiol., Lond. 193, 187–212 (1967).

    Article  CAS  Google Scholar 

  35. Yoshimura, K. J. Biochem. 74, 389–391 (1973).

    CAS  PubMed  Google Scholar 

  36. Rogus, M., Cheng, L. C. & Zierler, K. Biochim. Biophys. Acta 464, 347–355 (1977).

    Article  CAS  Google Scholar 

  37. St. Louis, P. J. & Sulakhe, P. V. Eur. J. Pharmac. 43, 277–280 (1977).

    Article  CAS  Google Scholar 

  38. Braughler, J. M. & Corder, C. N. Biochim. Biophys. Acta 524, 455–465 (1978).

    Article  CAS  Google Scholar 

  39. Burnstock, G. J. Physiol., Lond., 143, 183–194 (1958).

    Article  CAS  Google Scholar 

  40. Casteels, R., Droogmans, G. & Hendrickx, H. J. Physiol., Lond. 217, 297–313 (1971).

    Article  CAS  Google Scholar 

  41. El-Sharkawy, T. Y. & Daniel, E. E. Am. J. Physiol. 229, 1277–1286 (1975).

    CAS  PubMed  Google Scholar 

  42. Marshall, J. M. Fedn. Proc. 36, 2450–2455 (1977).

    CAS  Google Scholar 

  43. Brading, A. F. & Widdicombe, J. H. in Colloquium on Smooth Muscle, Pharmacology and Physiology (eds Worcel, M. & Vassort, G. ) (INSERM, Paris, 1976).

    Google Scholar 

  44. Reuter, H., Blaustein, M. P. & Haeusler, G. Phil. Trans. R. Soc. Lond. B265, 87–94 (1974).

    Article  Google Scholar 

  45. Blaustein, M. P. Am. J. Physiol. 232, C165–C173 (1977).

    Article  CAS  Google Scholar 

  46. Ma, T. S. & Bose, D. Am. J. Physiol. 232, C59–C66 (1977).

    Article  CAS  Google Scholar 

  47. Singer, J. J. & Fay, F. S. Am. J. Physiol. 232, C138–C143 (1977).

    Article  CAS  Google Scholar 

  48. Gilman, A. G. Proc. natn. Acad. Sci. U.S.A. 67, 305–312 (1970).

    Article  ADS  CAS  Google Scholar 

  49. Hardman, J. G., Mayer, S. E. & Clark, B. J. Pharmac. exp. Ther. 150, 341–348 (1965).

    CAS  Google Scholar 

  50. Keynes, R. D. Proc. R. Soc. Lond. 142, 359–382 (1954).

    ADS  CAS  PubMed  Google Scholar 

  51. Rubin, C. S., Erlichman, J. & Rosen, O. M. Meth. Enzym. 38, 308–315 (1974).

    Article  CAS  Google Scholar 

  52. Ray, T. K. & Forte, J. G. Biochim. biophys. Acta 443, 451–467 (1976).

    Article  CAS  Google Scholar 

  53. Schwartz, A., Lindenmayer, G. E. & Allen, J. C. Pharmac. Rev. 27, 3–134 (1975).

    CAS  Google Scholar 

  54. Jorgensen, P. L. Q. Rev. Biophys. 7, 239–274 (1975).

    Article  Google Scholar 

  55. Schwartz, A., Allen, J. C. & Harigay, S. J. Pharmac. Exp. Ther. 168, 31–41 (1969).

    CAS  Google Scholar 

  56. Walsh et al. J. biol. Chem. 246, 177–185 (1971).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605

    C. R. Scheid, T. W. Honeyman & F. S. Fay

Authors
  1. C. R. Scheid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. W. Honeyman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. S. Fay
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scheid, C., Honeyman, T. & Fay, F. Mechanism of β- adrenergic relaxation of smooth muscle. Nature 277, 32–36 (1979). https://doi.org/10.1038/277032a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/277032a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing