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Pc 1 Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis

Naturevolume 277pages2832 (1979) | Download Citation

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Abstract

PC 1 Duarte, a common variant of a human brain-specific protein, is present in one-third of the control population and has a gene frequency of 0.17. There was a significantly increased frequency of mutant heterozygotes and homozygotes among individuals with depressive disease. This is consistent with a model in which Pc 1 Duarte is the major gene in depressive disease, acting in conjunction with an environmental threshold effect.

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  1. Department of Medical Genetics, City of Hope National Medical Center, Duarte, California, 91010

    • David E. Comings

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https://doi.org/10.1038/277028a0

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