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Slow synaptic excitation mediated by serotonin in Auerbach's plexus


THE application of low concentrations of substance P to guinea-pig myenteric neurones has been reported by Katayama and North to produce depolarisation associated with an increase in input resistance and augmented excitability1. On this basis, they suggested that substance P may be involved in the production of the slow excitatory postsynaptic potential (e.p.s.p.) which can be evoked in myenteric neurones by electrical stimulation of the interganglionic connectives2. In this report, we show that application of serotonin (5-HT) mimics the slow e.p.s.p., and present several lines of evidence which suggest that 5-HT is a more likely candidate for the neurotransmitter of the slow e.p.s.p.

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WOOD, J., MAYER, C. Slow synaptic excitation mediated by serotonin in Auerbach's plexus. Nature 276, 836–837 (1978).

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