Abstract
OSTEOLYTIC bone metastases occur frequency in patients with advanced malignancy. Breast cancer, the most common malignant disease of women, metastasises to bone more frequently than to any other organ1, and over 80% of patients with advanced breast cancer develop bone metastases2–4. The cellular and molecular mechanisms of bone destruction in patients with cancer are not clearly understood. It has been postulated that there may be two mechanisms, one which is mediated by osteoclasts and one which occurs independently of osteoclasts5,6. We show here that cultured human breast cancer cells have the capacity to resorb directly in vitro, independently of osteoclast stimulation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Haagensen, C. D. Surgery 76, 685–714 (1974).
Sklaroff, D. M. & Charkes, N. D. Surg. Gynec. Obstet. 127, 763–768 (1968).
Galasko, C. S. B. Br. J. Surg. 56, 757–764 (1969).
Hoffman, H. C. & Marty, R., Am. J. Surg. 124, 194–199 (1972).
Galasko, C. S. B. Nature 263, 507–508 (1976).
Galasko, C. S. B. & Bennett, A. Nature 263, 508–510 (1976).
Soule, H. D. et al. J. natn. Cancer Inst. 51, 1409–1416 (1973).
Raisz, L. G. J. clin. Invest. 44, 103–116 (1965).
Trummel, C. L., Mundy, G. R. & Raisz, L. G. J. Lab. clin. Med. 85, 1001–1007 (1975).
Mundy, G. R., Altman, A. J., Gondek, M. D. & Bandelin, J. G. Science 196, 1109–1111 (1977).
Brand, J. S. & Raisz, L. G. Endocrinology 90, 479–487 (1972).
Holtrop, M. E. King, J. G. & Raisz, L. G. in Proc. 6th Parathyroid Conf. (eds Talmage, R. V. & Copp, H.) (Excerpta Medica, Amsterdam, in the press).
Mundy, G. R., Shapiro, J. I., Bandelin, J. G. & Raisz, L. G. J. clin. Invest. 58, 529–534 (1976).
Werner, J. A., Gorton, S. J. & Raisz, L. G. Endocrinology 90, 752–759 (1972).
Raisz, L. G. & Neiman, I. Endocrinology 85, 446–452 (1969).
Klein, D. C. & Raisz, L. G. Endocrinology 86, 1436–1440 (1970).
Horton, J. E., Raisz, L. G., Simmons, H. A., Oppenheim, J. J. & Mergenhagen, S. E. Science 177, 793–795 (1972).
Bray, M. A., Gordon, D. & Morley, J. Br. J. Pharmac. 52, 45P (1974).
Mundy, G. R., Raisz, L. G., Cooper, R. A., Schechter, G. P. & Salmon, S. E. New Engl. J. Med. 291, 1041–1406 (1974).
Klein, L. in Standard Methods in Clinical Chemistry (ed. McDonald, R. P.) 41–56 (Academic, New York, 1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
EILON, G., MUNDY, G. Direct resorption of bone by human breast cancer cells in vitro. Nature 276, 726–728 (1978). https://doi.org/10.1038/276726a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/276726a0
This article is cited by
-
Bone-Bound Bisphosphonates Inhibit Proliferation of Breast Cancer Cells
Calcified Tissue International (2019)
-
Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells
BMC Cancer (2015)
-
Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions
La radiologia medica (2007)
-
Physiopathology of cancer metastases in bone and of the changes they induce in bone remodeling
Rendiconti Lincei (2002)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.