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Accessory cell requirement for anti-IgM-induced proliferation of B lymphocytes


THE nature of the signals which B lymphocytes must receive so as to proliferate and differentiate are not yet completely understood. It is likely that B cells with different triggering requirements exist1,2, and that B-cell proliferation and B-cell differentiation require separate signals3–6. Because of this heterogeneity in signalling, it has been difficult to define precisely what is necessary to induce the expansion and differentiation of a particular B-cell clone after its exposure to antigen. It has been suggested that direct antigen binding to specific membrane immunoglobulin initiates at least one of the necessary activation signals7–9. Further activation signals may come from T cells and/or macrophages7–9. We have been studying the nature of the stimuli required for the induction of B-cell proliferation. We report here that using soluble goat anti-mouse IgM as a surface Ig cross-linking agent, we have confirmed that interactions with surface Ig can induce the proliferation of at least a subset of mouse B cells10–12. In addition, we have found a requirement for radioresistant phagocytic adherent cells in the polyclonal stimulation of B cells by this antibody.

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MONGINI, P., FRIEDMAN, S. & WORTIS, H. Accessory cell requirement for anti-IgM-induced proliferation of B lymphocytes. Nature 276, 709–711 (1978).

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