Abstract
MORE than 100 mutations affecting neurological function have been described in mice1. In one of these, staggerer2,3, the development of normal synaptic relationships between cerebellar granule cells and Purkinje cells is disturbed4–6. In a search for abnormalities in the cell surface of staggerer cerebellar cells, we have measured cell agglutination in the presence of the plant lectins concanavalin A (Con A) and wheat germ agglutinin (WGA). We report here that cell surface properties necessary for WGA-induced agglutination are abnormal in the mutant cerebellar cell population whereas those necessary for Con A-induced agglutination are not. These results are consistent with the persistence of a characteristic of the embryonic cerebellar cell surface.
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HATTEN, M., MESSER, A. Postnatal cerebellar cells from staggerer mutant mice express embryonic cell surface characteristic. Nature 276, 504–506 (1978). https://doi.org/10.1038/276504a0
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DOI: https://doi.org/10.1038/276504a0
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