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A suppressor mutation in the nematode acting on specific alleles of many genes

Nature volume 275, pages 715–719 (1978)Cite this article

Abstract

A suppressor mutation has been isolated in Caenorhabditis elegans through reversion analysis of a muscle-defective mutant. The suppressor mutation acts on specific alleles of at least six genes and in one case we have been able to show that it partially restores functional gene product to a mutant otherwise lacking that product. These and other features of the suppressor suggest that it acts at some step in information transfer, perhaps through mechanisms similar to those described previously in microorganisms.

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110

    Robert H. Waterston

  2. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    Sydney Brenner

Authors
  1. Robert H. Waterston
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  2. Sydney Brenner
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Waterston, R., Brenner, S. A suppressor mutation in the nematode acting on specific alleles of many genes. Nature 275, 715–719 (1978). https://doi.org/10.1038/275715a0

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