Abstract
NATURAL antibodies against antigenic sites on the Fc region of human and animal IgG are referred to collectively as rheumatoid factors (RF) and they represent one of the immunological hallmarks of rheumatoid arthritis (RA). Thus, the synovial fluid and tissue of RA patients contain large immune complexes which at least in part consist of RF1–4, and RF are present in serum in the majority of patients with definite or classical RA. Recent studies have demonstrated that purified and pepsin-digested polyclonal RF of IgG class from an RA serum (Han), in addition to reacting specifically with IgG, also bind to an antigen associated with cell nuclei from many species5. Furthermore, essentially 100% of the anti-nuclear antibodies (ANA) of two sera (Han, Jos) was absorbed by insolubilised human IgG; the antibodies which could be eluted from this immunosorbant bound to cell nuclei, and this binding was specifically inhibited by Fc fragments of human IgG5,6. We show here that RF from serum Jos bind to nucleosomes, the repeating histone–DNA subunit of chromatin.
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References
Hannestad, K. Clin. exp. Immun. 2, 511–529 (1967).
Hannestad, K. Clin. exp. Immun. 3, 671–690 (1968).
Winchester, R. J., Agnello, V. & Kunkel, H. G. Clin. exp. Immun. 6, 689–706 (1970).
Munthe, E. & Natvig, J. B. Clin. exp. Immun. 8, 249–262 (1971).
Hannestad, K. & Johannessen, A. Scand. J. Immun. 5, 541–547 (1976).
Hannestad, K. Scand. J. Immun. 7, 127–136 (1978).
Shaw, B. R., Herman, T. M., Kovacic, R. T., Beaudreau, G. S. & Van Holde, K. E. Proc. natn. Acad. Sci. U.S.A. 73, 505–509 (1976).
Thomas, J. D. & Kornberg, R. D. Proc. natn. Acad. Sci. U.S.A. 72, 2626–2630 (1975).
Weber, K. & Osborn, M. J. biol. Chem. 244, 4406–4412 (1969).
Studier, F. W. J. molec. Biol. 79, 237–248 (1973).
Hay, F. C., Nineham, L. J. & Roitt, I. M. Br. med. J. 3, 203–204 (1975).
Kornberg, R. D. A. Rev. Biochem. 46, 931–954 (1977).
Bauer, K. Naturwissenschaften 58, 364–365 (1971).
Johnston, M. F. & Eisen, H. N. J. Immun. 117, 1189–1196 (1976).
Michaelides, M. C. & Eisen, H. N. J. exp. Med. 140, 687–702 (1974).
Manjula, B. N., Richards, F. & Rosenstein, W. Immunochemistry 13, 929–937 (1976).
Bhattacharjee, A. K. & Glaudemans, C. P. J. J. Immun. 120, 411–413 (1978).
Tolleshaug, H. & Hannestad, K. Immunochemistry 12, 173–182 (1975).
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HANNESTAD, K., STOLLAR, B. Certain rheumatoid factors react with nucleosomes. Nature 275, 671–673 (1978). https://doi.org/10.1038/275671a0
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DOI: https://doi.org/10.1038/275671a0
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