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Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase

Nature volume 275, pages 420–423 (1978)Cite this article

Abstract

Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in Φ80ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalAr mutation. These results indicate that DNA gyrase is involved in transcription.

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Author information

Author notes

  1. C. L. Smith

    Present address: Department of Biological Sciences, Columbia University, New York, New York, 10027

Authors and Affiliations

  1. The Public Health Research Institute of The City of New York, Inc., 455 First Avenue, New York, New York, 10016

    C. L. Smith

  2. Research Institute for Microbial Diseases, Osaka University, Yamada-Kami, Suita, Osaka, Japan

    M. Kubo & F. Imamoto

Authors
  1. C. L. Smith
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  2. M. Kubo
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  3. F. Imamoto
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Smith, C., Kubo, M. & Imamoto, F. Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase. Nature 275, 420–423 (1978). https://doi.org/10.1038/275420a0

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