Abstract
THE action of certain neurotransmitters on receptors is associated with changes in the levels of cyclic nucleotides. Catecholamines, for example, increase cyclic AMP levels in both the central and peripheral nervous systems1. In the adult brain the cerebellum contains the highest levels of cyclic GMP (ref. 2), and these can be altered in vivo by manipulation of excitatory pathways3,4 and intraventricular injection of γ-aminobutyric acid or glutamate3,5, and in vitro by certain amino acid transmitter candidates6,7 and depolarising agents8. We show here that during a relatively short period in postnatal development, the excitatory amino acid, glutamate, elicits very large increases in the levels of cyclic GMP in slices of rat cerebellum, apparently located in the cells differentiating at this time.
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GARTHWAITE, J., BALÁZS, R. Supersensitivity to the cyclic GMP response to glutamate during cerebellar maturation. Nature 275, 328–329 (1978). https://doi.org/10.1038/275328a0
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DOI: https://doi.org/10.1038/275328a0
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