Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Fibronectins—adhesive glycoproteins of cell surface and blood

Nature volume 275, pages 179–184 (1978)Cite this article

Abstract

A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids. These proteins may have important roles in cellular adhesion, malignant transformation, reticuloendothelial system function, and embryonic differentiation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kuusela, P., Ruoslahti, E., Engvall, E. & Vaheri, A. Immunochemistry 13, 639–642 (1976).

    Article  CAS  PubMed  Google Scholar 

  2. Hynes, R. O. Biochim. biophys. Acta 458, 73–107 (1976).

    CAS  PubMed  Google Scholar 

  3. Yamada, K. M. & Pastan, I. Trends Biochem. Sci. 1, 222–224 (1976).

    Article  CAS  Google Scholar 

  4. Mosesson, M. Thrombos. Haemostas. 38, 742–750 (1977).

    Article  CAS  Google Scholar 

  5. Grinnell, F. Int. Rev. Cytol. 53, 65–144 (1978).

    Article  CAS  PubMed  Google Scholar 

  6. Vaheri, A. & Mosher, D. F. Biochim. biophys. Acta (in the press).

  7. Morrison, P., Edsall, R. & Miller, S. G. J. Am. chem. Soc. 70, 3103–3108 (1948).

    Article  CAS  PubMed  Google Scholar 

  8. Wolff, I., Timpl, R., Pecker, I. & Steffen, C. Vox Sang. 12, 443–456 (1967).

    Article  CAS  Google Scholar 

  9. Ross, R. & Bornstein, P. J. Cell Biol. 40, 366–381 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Muir, L. W., Bornstein, P. & Ross, R. Eur. J. Biochem. 64, 105–114 (1976).

    Article  CAS  PubMed  Google Scholar 

  11. Allen, C., Saba, T. M. & Molnar, J. J. reticuloendothel. Soc. 13, 410–423 (1973).

    CAS  PubMed  Google Scholar 

  12. Ruoslahti, E., Vaheri, A., Kuusela, P. & Linder, E. Biochim. biophys. Acta 322, 352–358 (1973).

    Article  CAS  PubMed  Google Scholar 

  13. Ruoslahti, E. & Vaheri, A. Nature 248, 789–791 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Gahmberg, C. G. & Hakomori, S. Proc. natn. Acad. Sci. U.S.A. 70, 3329–3333 (1973).

    Article  ADS  CAS  Google Scholar 

  15. Gahmberg, C. G. & Hakomori, S. Biochem. biophys. Res. Commun. 59, 283–291 (1974).

    Article  CAS  PubMed  Google Scholar 

  16. Klebe, R. J. Nature 250, 248–251 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Pearlstein, E. Nature 262, 497–500 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Klebe, R. J. et al. Expl Cell Res. 104, 119–125 (1977).

    Article  CAS  Google Scholar 

  19. Hynes, R. O. & Bye, J. M. Cell 3, 113–120 (1974).

    Article  CAS  PubMed  Google Scholar 

  20. Yamada, K. M. & Weston, J. A. Proc. natn. Acad. Sci. U.S.A. 71, 3492–3496 (1974).

    Article  ADS  CAS  Google Scholar 

  21. Robbins, P. W. et al. Cold Spring Harb. Symp. quant. Biol. 39, 1173–1180 (1974).

    Article  Google Scholar 

  22. Grinnell, F. Expl Cell Res. 97, 265–274 (1976).

    Article  CAS  Google Scholar 

  23. Mosesson, M. W. & Umfleet, R. A. J. biol. Chem. 245, 5728–5736 (1970).

    Article  CAS  PubMed  Google Scholar 

  24. Mosesson, M. W., Chen, A. B. & Huseby, R. M. Biochim. biophys. Acta 386, 509–524 (1975).

    Article  CAS  PubMed  Google Scholar 

  25. Mosher, D. F. J. biol. Chem. 250, 6614–6621 (1975).

    Article  CAS  PubMed  Google Scholar 

  26. Iwanaga, S., Suzuki, K. & Hashimoto, S. Ann. N. Y. Acad. Sci. 312, 56–73 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Ruoslahti, E. & Vaheri, A. J. exp. Med. 141, 497–501 (1975).

    Article  CAS  PubMed  Google Scholar 

  28. Stemberger, A. & Hormann, H. Hoppe-Seyler's Z. physiol. Chem. 357, 1003–1005 (1976).

    CAS  Google Scholar 

  29. Chen, L. B., Gallimore, P. H. & McDougall, J. K. Proc. natn. Acad. Sci. U.S.A. 73, 3570–3574 (1976).

    Article  ADS  CAS  Google Scholar 

  30. Vaheri, A., Ruoslahti, E., Westermark, B. & Ponten, J. J. exp. Med. 143, 64–72 (1976).

    Article  CAS  PubMed  Google Scholar 

  31. Burridge, K. Proc. natn. Acad. Sci. U.S.A. 73, 4457–4461 (1976).

    Article  ADS  CAS  Google Scholar 

  32. Mautner, V. M. & Hynes, R. O. J. Cell Biol. 75, 743–766 (1977).

    Article  CAS  PubMed  Google Scholar 

  33. Hedman, K., Vaheri, A. & Wartiovaara, J. J. Cell Biol. 76, 748–760 (1978).

    Article  CAS  PubMed  Google Scholar 

  34. Yamada, K. M. J. Cell Biol. 78, 520–541 (1978).

    Article  CAS  PubMed  Google Scholar 

  35. Yamada, K. M., Yamada, S. S. & Pastan, I. J. Cell Biol. 74, 649–654 (1977).

    Article  CAS  PubMed  Google Scholar 

  36. Chen, L. B., Maitland, N., Gallimore, P. H. & McDougall, J. K. Expl Cell. Res. 106, 39–46 (1977).

    Article  CAS  Google Scholar 

  37. Crouch, E., Balian, G., Holbrook, K., Duksin, D. & Bornstein, P. J. Cell Biol. (in the press).

  38. Birdwell, C. R., Gospodarowicz, D. & Nicholson, G. L. Proc. natn. Acad. Sci. U.S.A. 75, 273–277 (1978).

    Article  Google Scholar 

  39. Jaffe, E. A. & Mosher, D. F. J. exp. Med. 147, 1779–1791 (1978).

    Article  CAS  PubMed  Google Scholar 

  40. Wartiovaara, J., Linder, E., Ruoslahti, E. & Vaheri, A. J. exp. Med. 140, 1522–1533 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Bornstein, P. & Ash, J. F. Proc. natn. Acad. Sci. U.S.A. 74, 2480–2484 (1977).

    Article  ADS  CAS  Google Scholar 

  42. Schlessinger, J. et al. Proc. natn. Acad. Sci. U.S.A. 74, 2909–2913 (1977).

    Article  ADS  CAS  Google Scholar 

  43. Stenman, S., Wartiovaara, J. & Vaheri, A. J. Cell Biol. 74, 453–467 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Chen, L. B., Murray, A., Segal, R. A., Bushnell, A. & Walsh, M. L. Cell 14, 377–391 (1978).

    Article  CAS  PubMed  Google Scholar 

  45. Chen, L. B. et al. Ann. N. Y. Acad. Sci. 312, 366–381 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  46. Bornstein, P., Duksin, D., Balian, G., Davidson, J. & Crouch, E. Ann. N. Y. Acad. Sci. 312, 93–105 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  47. Furcht, L. T., Mosher, D. F. & Wendelschafer-Crabb, G. Cell 13, 263–271 (1978).

    Article  CAS  PubMed  Google Scholar 

  48. Graham, J. M., Hynes, R. O., Davidson, E. A. & Bainton, D. F. Cell 4, 353–365 (1975).

    Article  CAS  PubMed  Google Scholar 

  49. Marciani, D. J. & Bader, J. P. Biochim. biophys. Acta 401, 386–398 (1975).

    Article  CAS  PubMed  Google Scholar 

  50. Yamada, K. M., Yamada, S. S. & Pastan, I. Proc. natn. Acad. Sci. U.S.A. 72, 3158–3162. (1975).

    Article  ADS  CAS  Google Scholar 

  51. Yamada, K. M., Schlesinger, D. H., Kennedy, D. W. & Pastan, I. Biochemistry 16, 5552–5559 (1977).

    Article  CAS  PubMed  Google Scholar 

  52. Vaheri, A. & Ruoslahti, E. J. exp. Med. 142, 530–535 (1975).

    Article  CAS  PubMed  Google Scholar 

  53. Critchley, D. R., Wyke, J. A. & Hynes, R. O. Biochim. biophys. Acta 436, 335–352 (1976).

    Article  CAS  PubMed  Google Scholar 

  54. Sear, C. H. J., Grant, M. E. & Jackson, D. S. Biochem. biophys. Res. Commun. 71, 379–384 (1976).

    Article  CAS  PubMed  Google Scholar 

  55. Olden, K. & Yamada, K. M. Cell 11, 957–969 (1977).

    Article  CAS  PubMed  Google Scholar 

  56. Ali, I. U., Mautner, V. M., Lanza, R. & Hynes, R. O. Cell 11, 115–126 (1977).

    Article  CAS  PubMed  Google Scholar 

  57. Mosher, D. F., Saksela, O., Keski-Oja, J. & Vaheri, A. J. supramolec. Structure 6, 551–664 (1977).

    Article  CAS  Google Scholar 

  58. Baum, B. J., McDonald, J. A. & Crystal, R. G. Biochem. biophys. Res. Commun. 79, 8–15 (1977).

    Article  CAS  PubMed  Google Scholar 

  59. Linder, E., Vaheri, A., Ruoslahti, E. & Wartiovaara, J. J. exp. Med. 142, 41–49 (1975).

    Article  CAS  PubMed  Google Scholar 

  60. Stenman, S. & Vaheri, A. J. exp. Med. 147, 1054–1064 (1978).

    Article  CAS  PubMed  Google Scholar 

  61. Zetter, B. R. & Martin, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 2324–2328 (1978).

    Article  ADS  CAS  Google Scholar 

  62. Wartiovaara, J., Stenman, S. & Vaheri, A. Differentiation 5, 85–89 (1976).

    Article  CAS  PubMed  Google Scholar 

  63. Chen, A. B., Mosesson, M. W. & Solish, G. I. Am. J. Obstet. Gynecol. 7, 958–961 (1976).

    Article  Google Scholar 

  64. Kuusela, P., Vaheri, A., Palo, J. & Ruoslahti, E. J. Lab. clin. Med. (in the press).

  65. Stathakis, N. E. & Mosesson, M. W. J. clin. Invest. 60, 855–865 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Keski-Oja, J., Mosher, D. F. & Vaheri, A. Cell 9, 29–35 (1976).

    Article  CAS  PubMed  Google Scholar 

  67. Mosher, D. F. Biochim. biophys. Acta 491, 205–210 (1977).

    Article  CAS  PubMed  Google Scholar 

  68. Aronsen, K. F., Ekelund, G., Kindmark, C. O. & Laurell, C. B. Scand. J. clin. Lab. Invest. 29, Suppl. 124, 127–136 (1972).

    Article  Google Scholar 

  69. Kaplan, J. E., Molnar, J., Saba, T. M. & Allen, C. J. reticuleondothel. Soc. 20, 375–384 (1976).

    CAS  Google Scholar 

  70. Kaplan, J. E. & Saba, T. M. Am. J. Physiol. 230, 7–14 (1976).

    Article  CAS  PubMed  Google Scholar 

  71. Blumenstock, F., Weber, P., Saba, T. M. & Laffin, R. Am. J. Physiol., Regulatory Integrative Comp. Physiol. 1, R80–R87 (1977).

    Article  Google Scholar 

  72. Mosesson, M. W. Ann. N. Y. Acad. Sci. 312, 11–30 (1978).

    Article  ADS  CAS  Google Scholar 

  73. Forkman, B., Ganrot, P. O., Gennser, G. & Rannevik, G. Scand. J. clin. Lab. Invest. 29, Suppl. 124, 89–96 (1972).

    Article  Google Scholar 

  74. Stone, K. R., Smith, R. E. & Joklik, W. K. Virology 58, 86–100 (1974).

    Article  CAS  PubMed  Google Scholar 

  75. Wickus, G. G., Branton, P. E. & Robbins, P. W. in Proliferation in Animal Cells (eds Clarkson, B. & Baserga, R.) (Cold Spring Harbor Laboratory, New York, 1974).

    Google Scholar 

  76. Vaheri, A. & Ruoslahti, E. Int. J. Cancer 13, 579–586 (1974).

    Article  CAS  PubMed  Google Scholar 

  77. Hynes, R. O. & Wyke, J. A. Virology 64, 492–504 (1975).

    Article  CAS  PubMed  Google Scholar 

  78. Keski-Oja, J., Vaheri, A. & Ruoslahti, E. Int. J. Cancer 17, 261–269 (1976).

    Article  CAS  PubMed  Google Scholar 

  79. Hawkes, S. P., Meehan, T. D. & Bissell, M. J. Biochem. biophys. Res. Commun. 68, 1226–1233 (1976).

    Article  CAS  PubMed  Google Scholar 

  80. Royer-Pokora, B. et al. Cell 13, 751–760 (1978).

    Article  CAS  PubMed  Google Scholar 

  81. Clarke, S. M. & Fink, L. M. Cancer Res. 37, 2985–2992 (1977).

    CAS  PubMed  Google Scholar 

  82. Hynes, R. O. Proc. natn. Acad. Sci. U.S.A. 70, 3170–3174 (1973).

    Article  ADS  CAS  Google Scholar 

  83. Critchley, D. R. Cell 3, 121–125 (1974).

    Article  CAS  PubMed  Google Scholar 

  84. Hynes, R. O., Wyke, J. A., Bye, J. M., Humphryes, K. C. & Pearlstein, E. S. in Proteases and Biological Control (Cold Spring Harbor Laboratory, New York, 1975).

    Google Scholar 

  85. Gahmberg, C. G., Kiehn, D. & Hakomori, S. Nature 248, 413–415 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  86. Pearlstein, E. & Waterfield, M. D. Biochim. biophys. Acta 362, 1–12 (1974).

    Article  CAS  PubMed  Google Scholar 

  87. Pearlstein, E., Hynes, R. O., Franks, L. M. & Hemmings, V. J. Cancer Res. 36, 1475–1480 (1976).

    CAS  PubMed  Google Scholar 

  88. VanNest, G. A. & Grimes, W. J. Biochemistry 16, 2902–2907 (1977).

    Article  CAS  Google Scholar 

  89. Hogg, N. W. Proc. natn. Acad. Sci. U.S.A. 71, 489–492 (1974).

    Article  ADS  CAS  Google Scholar 

  90. Itaya, K. & Hakomori, S. FEBS Lett. 66, 65–69 (1976).

    Article  CAS  PubMed  Google Scholar 

  91. Shopsis, C. & Sheinin, R. Biochim. biophys. Acta 433, 101–117 (1976).

    Article  CAS  PubMed  Google Scholar 

  92. Jones, P. A. et al. Cancer Res. 36, 2863–2867 (1976).

    CAS  PubMed  Google Scholar 

  93. Hunt, R. C., Gold, E. & Brown, J. C. Biochim. biophys. Acta 413, 453–458 (1975).

    Article  CAS  PubMed  Google Scholar 

  94. Olden, K., Willingham, M. & Pastan, I. Cell 8, 383–390 (1976).

    Article  CAS  PubMed  Google Scholar 

  95. Marciani, D. J., Lyons, L. B. & Thompson, E. B. Cancer Res. 36, 2937–2944 (1976).

    CAS  PubMed  Google Scholar 

  96. Noonan, K. D., Wright, P. J., Bouck, N. & DiMayorca, G. J. Virol. 18, 1134–1138 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Rieber, M. & Irwin, J. C. Cancer Res. 34, 3469–3473 (1974).

    CAS  PubMed  Google Scholar 

  98. Hynes, R. O., Martin, G. S., Shearer, M., Critchley, D. R. & Epstein, C. J. Devl Biol. 48, 35–46 (1976).

    Article  CAS  Google Scholar 

  99. Gallimore, P. H., McDougall, J. K. & Chen, L. B. Cell 10, 669–678 (1977).

    Article  CAS  PubMed  Google Scholar 

  100. Becker, D., Kurth, R., Critchley, D., Friis, R. & Heinz, B. J. Virol. 21, 1042–1055 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Blumberg, P. M., Driedger, P. E. & Rossow, P. W. Nature 264, 446–447 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  102. Yamada, K. M., Olden, K. & Pastan, I. Ann. N. Y. Acad. Sci. 312, 256–277 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  103. Yamada, K. M., Yamada, S. S. & Pastan, I. Proc. natn. Acad. Sci. U.S.A. 73, 1217–1221 (1976).

    Article  ADS  CAS  Google Scholar 

  104. Willingham, M. C., Yamada, K. M., Yamada, S. S., Pouyssegur, J. & Pastan, I. Cell 10, 375–380 (1977).

    Article  CAS  PubMed  Google Scholar 

  105. Millis, A. J. T. & Hoyle, M. Nature 271, 668–669 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  106. Klebe, R. J. J. cell. Physiol. 86, 231–236 (1975).

    Article  CAS  PubMed  Google Scholar 

  107. Hynes, R. O. et al. Ann. N. Y. Acad. Sci. 312, 317–342 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  108. Grinnell, F. Expl Cell Res. 97, 265–274 (1976).

    Article  CAS  Google Scholar 

  109. Grinnell, F. Expl Cell Res. 102, 51–62 (1976).

    Article  CAS  Google Scholar 

  110. Grinnell, F., Hays, D. G. & Minter, D. Expl Cell Res. 110, 175–190 (1977).

    Article  CAS  Google Scholar 

  111. Hook, M., Rubin, K., Oldberg, A., Obrink, D. & Vaheri, A. Biochem. biophys. Res. Commun. 79, 726–733 (1977).

    Article  CAS  PubMed  Google Scholar 

  112. Grinnell, F. & Hays, D. G. Expl Cell Res. (in the press).

  113. Pena, S. D. J. & Hughes, R. C. Cell Biol. International Repts (in the press).

  114. Macarak, E. J., Kirby, E., Kirk, T. & Kefalides, N. A. Proc. natn. Acad. Sci. U.S.A. 75, 2621–2625 (1978).

    Article  ADS  CAS  Google Scholar 

  115. Engvall, E. & Ruoslahti, E. Int. J. Cancer 20, 1–5 (1977).

    Article  CAS  PubMed  Google Scholar 

  116. Dessau, W., Adelmann, B. C., Timpl, R. & Martin, G. R. Biochem. J. 169, 55–59 (1978).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Engvall, E., Ruoslahti, E. & Miller, E. J. J. exp. Med. 147, 1584–1595 (1978).

    Article  CAS  PubMed  Google Scholar 

  118. Kleinman, H. K., McGoodwin, E. B. & Klebe, R. J. Biochim. biophys. Res. Commun. 72, 426–432 (1976).

    Article  CAS  Google Scholar 

  119. Blumenstock, F., Saba, T. M., Weber, P. & Cho, E. J. reticuloendothel. Soc. 19, 157–172 (1976).

    CAS  PubMed  Google Scholar 

  120. Blumenstock, F., Weber, P. & Saba, T. M. J. biol. Chem. 252, 7156–7162 (1977).

    Article  CAS  PubMed  Google Scholar 

  121. Blumenstock, F. A., Saba, T. M. & Weber, P. J. reticuloendothel. Soc. 23, 119–134 (1978).

    CAS  PubMed  Google Scholar 

  122. Maurer, P. H. J. exp. Med. 100, 497–513 (1954).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Hopper, K. E., Adelman, B. C., Gentner, G. & Gay, S. Immunology 30, 249–259 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  124. Dessau, W., Jilek, F., Adelmann, B. C. & Hormann, H. Biochim. biophys. Acta 533, 227–237 (1978).

    Article  CAS  PubMed  Google Scholar 

  125. Saba, T. M., Blumenstock, F. A., Weber, P. & Kaplan, J. E. Ann. N. Y. Acad. Sci. 312, 43–55 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  126. Blumenstock, F. A., Saba, T. M., Weber, P. & Laffin, R. J. biol. Chem. 253, 4287–4291 (1978).

    Article  CAS  PubMed  Google Scholar 

  127. Yamada, K. M., Ohanian, S. H. & Pastan, I. Cell 9, 241–245 (1976).

    Article  CAS  PubMed  Google Scholar 

  128. Abercrombie, M. In Vitro 6, 128–142 (1970).

    Article  CAS  PubMed  Google Scholar 

  129. Weber, M. J., Hale, A. H. & Losasso, L. Cell 10, 45–51 (1977).

    Article  CAS  PubMed  Google Scholar 

  130. Bell, P. B. J. Cell Biol. 74, 963–982 (1977).

    Article  PubMed  PubMed Central  Google Scholar 

  131. Weston, J. A. & Hendricks, K. L. Proc. natn. Acad. Sci. U.S.A. 69, 3727–3731 (1972).

    Article  ADS  CAS  Google Scholar 

  132. Pouyssegur, J., Willingham, M. & Pastan, I. Proc. natn. Acad. Sci. U.S.A. 74, 243–247 (1977).

    Article  ADS  CAS  Google Scholar 

  133. Ali, I. U. & Hynes, R. O. Cell 14, 439–446 (1978).

    Article  CAS  PubMed  Google Scholar 

  134. Zetter, B. R., Chen, L. B. & Buchanan, J. M. Cell 7, 407–412 (1976).

    Article  CAS  PubMed  Google Scholar 

  135. Yamada, K. M. & Pastan, I. J. Cell. Physiol. 89, 827–830 (1976).

    Article  CAS  PubMed  Google Scholar 

  136. Teng, N. N. H. & Chen, L. B. Proc. natn. Acad. Sci. U.S.A. 72, 413–417 (1975).

    Article  ADS  CAS  Google Scholar 

  137. Blumberg, P. M. & Robbins, P. W. Cell 6, 137–147 (1975).

    Article  CAS  PubMed  Google Scholar 

  138. Alexander, S. S., Colonna, G., Yamada, K. M., Pastan, I. & Edelhoch, H. J. biol. Chem. (in the press).

  139. Keski-Oja, J., Mosher, D. F. & Vaheri, A. Biochem. biophys. Res. Commun. 74, 699–706 (1977).

    Article  CAS  PubMed  Google Scholar 

  140. Hynes, R. O. & Destree, A. Proc. natn. Acad. Sci. U.S.A. 74, 2855–2859 (1977).

    Article  ADS  CAS  Google Scholar 

  141. Chen, A. B., Amrami, D. L. & Mosesson, M. W. Biochim. biophys. Acta 493, 310–322 (1977).

    Article  CAS  PubMed  Google Scholar 

  142. Jilek, F. & Hormann, H. Hoppe-Seyler's Z. physiol. Chem. 359, 247–250 (1978).

    CAS  Google Scholar 

  143. Ali, I. U. & Hynes, R. O. Biochim. biophys. Acta 510, 140–150 (1978).

    Article  CAS  PubMed  Google Scholar 

  144. Carter, W. G. & Hakomori, S. Biochem. biophys. Res. Commun. 76, 299–307 (1977).

    Article  CAS  Google Scholar 

  145. Vuento, M., Wrann, M. & Ruoslahti, E. FEBS Lett. 82, 227–231 (1977).

    Article  CAS  PubMed  Google Scholar 

  146. Nairn, R. & Hughes, R. C. Biochem. Soc. Trans. 4, 165–167 (1976).

    Article  CAS  PubMed  Google Scholar 

  147. Hynes, R. O., Destree, A. T. & Mautner, V. J. supramolec. Structure 9, 189–202 (1976).

    CAS  Google Scholar 

  148. Olden, K., Pratt, R. M. & Yamada, K. M. Cell 13, 461–473 (1978).

    Article  CAS  PubMed  Google Scholar 

  149. Carter, W. G., Fukuda, M. & Hakomori, S. Ann. N. Y. Acad. Sci. 312, 160–177 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  150. Duksin, D. & Bornstein, P. J. biol. Chem. 252, 955–962 (1977).

    Article  CAS  PubMed  Google Scholar 

  151. Robbins, J. C. & Nicolson, G. in Cancer: A Comprehensive Treatise Vol. 4 (ed. Becker, E. F.) (Plenum, New York, 1975).

    Google Scholar 

  152. Yamada, K. M. & Weston, J. A. Cell 5, 75–81 (1974).

    Article  Google Scholar 

  153. Rieber, M., Bacalao, J. & Alonso, G. Cancer Res. 35, 2104–2108 (1975).

    CAS  PubMed  Google Scholar 

  154. Chen, L. B., Gudor, R. C., Sun, T. T., Chen, A. B. & Mosesson, M. W. Science 197, 776–778 (1977).

    Article  ADS  CAS  PubMed  Google Scholar 

  155. Mosher, D. F. & Vaheri, A. Expl Cell Res. 112, 323–334 (1978).

    Article  CAS  Google Scholar 

  156. Chen, L. B., Moser, F. G., Chen, A. B. & Mosesson, M. W. Expl Cell Res. 108, 375–383 (1977).

    Article  CAS  Google Scholar 

  157. Adams, S. L. et al. Proc. natn. Acad. Sci. U.S.A. 74, 3399–3403 (1977).

    Article  ADS  CAS  Google Scholar 

  158. Hynes, R. O., Destree, A. T., Mautner, V. M. & Ali, I. U. J. supramol. Structure (in the press).

  159. Chen, L. B. Cell 10, 393–400 (1977).

    Article  CAS  PubMed  Google Scholar 

  160. Hassell, J. R., Pennypacker, J. P., Yamada, K. M. & Pratt, R. M. Ann. N. Y. Acad. Sci. 312, 406–409 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  161. Noonan, K. D., Lindberg, D. S. & McClure, J. A. J. supramolec. Structure, Suppl. 1, 245–259 (1976).

  162. Culp, L. A. Biochemistry 15, 4094–4104 (1976).

    Article  CAS  PubMed  Google Scholar 

  163. Pollack, R. & Rifkin, D. Cell 6, 495–506 (1975).

    Article  Google Scholar 

  164. Ali, I. U. & Hynes, R. O. Biochim. biophys. Acta 471, 16–24 (1977).

    Article  CAS  PubMed  Google Scholar 

  165. Kurkinen, M., Wartiovaara, J. & Vaheri, A. Expl Cell Res. 111, 127–137 (1978).

    Article  CAS  Google Scholar 

  166. Kurkinen, M. & Vaheri, A. Cell Biol. International Repts 1, 469–475 (1977).

    Article  CAS  Google Scholar 

  167. Albrecht-Buehler, G. & Chen, L. B. Nature 266, 454–456 (1977).

    Article  ADS  CAS  PubMed  Google Scholar 

  168. Saba, T. M. & Antikatzides, T. G. Br. J. Cancer 32, 471–481 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  169. Saba, T. M. & Cho, E. J. reticuloendothel. Soc. 22, 583–596 (1977).

    CAS  PubMed  Google Scholar 

  170. Moscona, A. A. in Cell Biology and Medicine (ed. Bittar, E.) (Wiley Interscience, NewYork, 1973).

    Google Scholar 

  171. Pastan, I. & Willingham, M. C. Nature 274, 645–650 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  172. Yamada, K. M. & Kennedy, D. U. (in preparation).

  173. Weston, J. A., Yamada, K. M. and Hendricks, K. L. (in preparation).

  174. Dessau, W., Sasse, J., Timpl, R. & von der Mark, K. Ann. N. Y. Acad. Sci. 312, 404–405 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  175. Pennypacker, J. P., Hassell, J. R., Yamada, K. M. & Pratt, R. M. (in preparation).

Download references

Author information

Authors and Affiliations

  1. Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, 20014

    Kenneth M. Yamada & Kenneth Olden

Authors
  1. Kenneth M. Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenneth Olden
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamada, K., Olden, K. Fibronectins—adhesive glycoproteins of cell surface and blood. Nature 275, 179–184 (1978). https://doi.org/10.1038/275179a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/275179a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing