Abstract
KASSNER1 has proposed that the apolarity of the haem environment primarily determines the oxidation–reduction potential, E′0pH 7.0, of a haem protein. Since high resolution crystallographic models are now available for six haem proteins with E′0 values of between 20 and 320 mV, I have tested the Kassner proposal by comparing the kinds of atoms contacting the haem in each of these proteins. The results demonstrate that the apolarity of the total haem environment for these proteins is virtually identical but that the E′0 value is inversely dependent on the exposure of the haem to an aqueous solvent.
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References
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STELLWAGEN, E. Haem exposure as the determinate of oxidation–reduction potential of haem proteins. Nature 275, 73–74 (1978). https://doi.org/10.1038/275073a0
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DOI: https://doi.org/10.1038/275073a0
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