Abstract
ALBUMIN is initially synthesised in the liver as preproalbumin1. This has an N-terminal peptide which is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to give the secreted albumin2. We report here the finding of a family with a circulating variant of proalbumin. This provides information on the structure of human proalbumin and the specificity of the propeptide cleavage site. It also raises the problem of the biological function of the propeptide and the necessity for cleavage.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Strauss, A. W., Donohue, A. M., Bennett, C. D., Rodkey, J. A. & Alberts, A. W. Proc. natn. Acad. Sci. U.S.A. 74, 1358 (1977).
Judah, J. D. & Quinn, P. S. Nature 271, 384 (1978).
Nelson, C., Noelkan, M., Buckley, C., Tanford, C. & Hill, R. Biochemistry 4, 1418 (1965).
Chua, C. G., Carrell, R. W. & Howard, B. H. Biochem. J. 149, 259 (1975).
Gray, W. R. Meth. Enzym. 25, 333 (1972).
Weiner, A. M., Platt, T. & Weber, K. J. biol. Chem. 247, 3242 (1972).
Russell, J. H. & Geller, D. M. J. biol. Chem. 250, 3409 (1975).
Judah, J. D. & Quinn, P. S. Trends biochem. Sci. 1, 107 (1976).
Lernmark, A. et al. Ciba Fdn Symp. 41, 7 (1976).
Rosen, A. M. & Geller, D. M. Biochem. biophys. Res. Commun. 78, 1060 (1977).
Schreiber, G., Urban, J. & Edwards, K. J. theor. Biol. 60, 241 (1976).
Lau, S. J. & Bibudhendra, S. J. biol. Chem. 246, 5938 (1971).
Appleton, D. W. & Sarkar, B. J. biol. Chem. 246, 5040 (1971).
Peters, T. in The Plasma Proteins, Vol. 1 (ed. Putman, F. W.) 133 (Academic, New York, 1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRENNAN, S., CARRELL, R. A circulating variant of human proalbumin. Nature 274, 908–909 (1978). https://doi.org/10.1038/274908a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/274908a0
This article is cited by
-
Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic Beta cell
Diabetologia (1991)
-
Production of Correctly Processed Human Serum Albumin in Transgenic Plants
Nature Biotechnology (1990)
-
Synthesis and Purification of Mature Human Serum Albumin from E. Coli
Nature Biotechnology (1987)
-
Precursors to regulatory peptides: their proteolytic processing
Experientia (1987)
-
Human biochemical genetics of enzyme proteins in the new age of molecular genetics
Journal of Inherited Metabolic Disease (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.