Letter | Published:

Specific suppression of antigen-reactive cells in neonatal transplantation tolerance

Nature volume 274, pages 895897 (31 August 1978) | Download Citation



ANALYSES of allogeneic immunological reactivity of neonatally tolerant animals at the cellular level have produced mixed results. Some investigators have observed complete nonreactivity and others have described variable, though well defined, specific reactivity in the mixed lymphocyte culture or in the cytotoxicity test. These findings can be explained by the different degree of tolerance achieved1,2 and by the different intensity of the suppressor mechanisms which may be involved in neonatal transplantation tolerance3–5. We report here an analysis of immunological reactivity in two experimental systems of neonatal tolerance in mice involving the disparity in either the entire H–2 complex or the D region only. We find that cells from tolerant animals nonreactive in the cytotoxicity test in vitro can be separated into nonadherent and nylonadherent cells according to adherence to nylon wool. The former cells, when sensitised in vitro, are cytotoxic, as are the sensitised cells from normal animals. The latter remain nonreactive even after the sensitisation and, in addition, specifically inhibit the in vitro sensitisation of cells from normal animals.

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  1. Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 5, Czechoslovakia

    •  & MILAN HAŠEK


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