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Transformation by concanavalin A of the response of molluscan neurones to L-glutamate

Nature volume 274, pages 866869 (31 August 1978) | Download Citation

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Abstract

Concanavalin A causes in all Aplysia and Helix neurones a depolarising response to L-glutamate. The Con A-induced glutamate response is pharmacologically distinct from the three cell-specific glutamate responses (two inhibitory, one excitatory) that can be elicited from untreated molluscan neurones. The transformation in glutamate sensitivity brought about by Con A does not seem to be related to the lectin's capacity to produce redistribution of receptor sites in cell membranes.

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Affiliations

  1. Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46, rue d'Ulm, 75005 Paris, France

    • JacSue Kehoe

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https://doi.org/10.1038/274866a0

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