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Muscular fatigue investigated by phosphorus nuclear magnetic resonance

Nature volume 274, pages 861866 (31 August 1978) | Download Citation

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Abstract

Muscular fatigue has been studied using 31P NMR to measure the levels and rates of utilisation of several key metabolites and the free-energy change for ATP hydrolysis. Force development is closely correlated with metabolite levels and is proportional to the rate at which ATP is hydrolysed.

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References

  1. 1.

    , & J. Physiol., Lond. 267, 703–735 (1977).

  2. 2.

    , & NMR in Biology (eds Dwek, R. A., Campbell, I. D., Richards, R. E. & Williams, R. J. P.) 289–322 (Academic, London, 1977).

  3. 3.

    Lehrbuch der physiologischen Chemie, 1850; and page 98 in 2nd edn translated by Day, G. E. (Cavendish Society, London, 1851).

  4. 4.

    , , , & J. supramolec. Struct. 3, 125–140 (1975).

  5. 5.

    , , & J. Physiol., Lond. 218, 163–193 (1971).

  6. 6.

    Mem. Acad. r. Belg. Cl. Sci. 8°serie 2, 32, 1–169 (1960).

  7. 7.

    J. Physiol., Lond. 66, 19–31 (1928).

  8. 8.

    A. Rev. Physiol. 28, 17–38 (1966).

  9. 9.

    , & J. biol. Chem. 210, 83–95 (1954).

  10. 10.

    & Proc. natn. Acad. Sci. U.S.A. 74, 4271–4275 (1977).

  11. 11.

    J. biol. Chem. 244, 3290–3302 (1969).

  12. 12.

    & Proc. natn. Acad. Sci. U.S.A. 64, 763–770 (1969).

  13. 13.

    thesis, Oxford Univ. (1974).

  14. 14.

    et al. Nature 252, 285–287 (1974).

  15. 15.

    , & J. biol. Chem. 251, 2584–2591 (1976).

  16. 16.

    , & Am. J. Physiol. 232, C185–C190.(1977).

  17. 17.

    , & Pflügers Arch. 334, 222–239 (1972).

  18. 18.

    & Am. J. Physiol 219, 1490–1495, (1970).

  19. 19.

    , & Q. Rev. Biophys. 9, 217–281 (1976).

  20. 20.

    & J. Physiol., Lond. 276, 233–255 (1978).

  21. 21.

    Quantities, Units and Symbols, (The Royal Society, London, 1975).

  22. 22.

    , & Can. J. Physiol. Pharmac. 50, 143–155 (1972).

  23. 23.

    & Physiol. Rev. (in the press).

  24. 24.

    J. Physiol., Lond. 68, 49–66 (1929/1930).

  25. 25.

    & Am. J. Physiol. 232, C30–C36 (1977).

  26. 26.

    & J. Physiol., Lond. 55, 133–158 (1921).

  27. 27.

    Le Couplage Energetique de la Contraction Musculaire (Arscia, Brussels, 1956).

  28. 28.

    & Biochim. biophys. Acta 70, 53–67 (1963).

  29. 29.

    , , & J. gen. Physiol. 65, 1–21 (1975).

  30. 30.

    , , & J. Physiol., Lond. 238, 455–472 (1974).

  31. 31.

    , , & J. Physiol., Lond. 220, 601–625 (1972).

  32. 32.

    J. Physiol., Lond. 220, 583–599 (1972).

  33. 33.

    , & Biochemistry 15, 4850–4853 (1977).

  34. 34.

    , , , & Archs Biochem. Biophys. 182, 683–689 (1977).

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Affiliations

  1. Department of Physiology, University College London Gower Street, London WC1

    • M. Joan Dawson
    • , D. G. Gadian
    •  & D. R. Wilkie
  2. Department of Biochemistry, University of Oxford, Oxford, UK

    • M. Joan Dawson

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https://doi.org/10.1038/274861a0

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