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New factor released by cultured glioma cells supporting survival and growth of sensory neurones

Naturevolume 274page818 (1978) | Download Citation



PROCESS formation can be induced in clonal neuroblastoma cells by a macromolecule termed glial factor which has been identified in medium conditioned by cultured C-6 glioma cells1. Fibre outgrowth can also be elicited in cultures of peripheral sensory neurones2 by the well-characterised mouse sub-maxillary gland nerve growth factor (NGF)3, which has been shown to be a different entity from glial factor4. We report here that glioma-conditioned medium (GCM), the source of glial factor, can support both survival and fibre formation of isolated chick sensory neurones and that neither NGF nor glial factor are responsible for this effect.

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    • R. M. LINDSAY

    Present address: Laboratory of Neurobiology, National Institute for Medical Research, Mill Hill, London, NW7, UK


  1. Department of Pharmacology, Biozentrum der Universität, Klingelbergstrasse 70, CH-4056, Basel, Switzerland

    • Y. A. BARDE
    •  & H. THOENEN
  2. Friedrich Miescher Institut, Postfach 273, CH-4002, Basel, Switzerland

    • R. M. LINDSAY
    •  & D. MONARD


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