Letter | Published:

Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture

Nature volume 274, pages 813816 (24 August 1978) | Download Citation

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Abstract

THE increasing use of tissue culture techniques in neurobiological studies has created an urgent need for cell-type specific markers which would allow unambiguous identification of the different types of neural cells. We show here that galactocerebroside (GC), the major glycolipid in myelin1, can serve as such a cell-surface marker for cultured rat oligodendrocytes, the glial cells responsible for making myelin in the central nervous system.

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References

  1. 1.

    & J. Neurochem. 13, 213–222 (1966).

  2. 2.

    , , & J. Immun. Meth. 11, 185–193 (1976).

  3. 3.

    , & Immunology 26, 743–757 (1974).

  4. 4.

    , & J. Lipid Res. 6, 525–533 (1965).

  5. 5.

    J. Lipid Res. 7, 449–451 (1966).

  6. 6.

    , , , & Brain Res. 147, 410–415 (1978).

  7. 7.

    , , & Ann. N.Y. Acad. Sci. 122, 266–276 (1965).

  8. 8.

    , & Nature 266, 364–366 (1977).

  9. 9.

    Z. Zellforsch. 94, 293–324 (1969).

  10. 10.

    , & J. comp. Neurol. 169, 313–323 (1976).

  11. 11.

    , , & Brain Res. 28, 351–354 (1971).

  12. 12.

    , , & Brain Res. 43, 429–435 (1972).

  13. 13.

    & Brain Res. 116, 150–157 (1976).

  14. 14.

    , , , & J. Cell Biol. 75, 67–73 (1977).

  15. 15.

    , & J. comp. Neurol. 165, 197–208 (1976).

  16. 16.

    , & J. Neurochem. 29, 329–334 (1977).

  17. 17.

    , , , & Brain Res. 148, 251–259 (1978).

  18. 18.

    J. Neurochem. 24, 647–654 (1975).

  19. 19.

    , & J. biol. Chem. 252, 2777–2779 (1977).

  20. 20.

    , & Brain Res. 89, 363–367 (1975).

  21. 21.

    , , & FEBS Lett. 83, 207–211 (1977).

  22. 22.

    , , & Devl Biol. 59, 206–227 (1977).

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Affiliations

  1. MRC Neuroimmunology Project, Zoology Department, University College London, London WC1, UK

    • MARTIN C. RAFF
    • , RHONA MIRSKY
    •  & K. L. FIELDS
  2. Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

    • ROBERT P. LISAK
    • , SUSAN H. DORFMAN
    •  & DONALD H. SILBERBERG
  3. Anatomy Department, Guy's Hospital Medical School, London SE1, UK

    • N. A. GREGSON
    • , SIDNEY LEIBOWITZ
    •  & MARY C. KENNEDY

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https://doi.org/10.1038/274813a0

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