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Cytochalasin D induces the capping of both leukaemia viral proteins and actin in infected cells

Nature volume 274, pages 808–809 (1978)Cite this article

Abstract

IT has been reported that cytochalasin B (CB) inhibits a cell-cycle-dependent step of Kirsten murine sarcoma–leukaemia virus maturation1. As CB inhibits hexose transport and acts on contractile elements2, the inhibition of virus maturation could be due to a hexose deficiency, the disruption of microfilaments, or some combination of the two effects. Because cytochalasin D (CD) seems to have only one effect, the disruption of microfilaments3–6, we used it here to study the role of microfilament organisation in the production of Moloney murine leukaemia virus (MLV). We report that actin and MLV structural proteins co-migrate in infected cells after CD treatment.

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References

  1. Panem, S. Virology 76, 146–151 (1977).

    Article  CAS  Google Scholar 

  2. Lin, S., Santi, D. V. & Spudich, J. A. J. biol. Chem. 249, 2268–2274 (1974).

    CAS  PubMed  Google Scholar 

  3. Asano, A. et al. Symp. Cell Biol., Okayama 26, 39–45 (1974).

    CAS  Google Scholar 

  4. Mimura, N. & Asano, A. Nature 261, 319–321 (1976).

    Article  ADS  CAS  Google Scholar 

  5. Tannenbaum, J., Tanenbaum, S. W., Lo, L. W., Godman, G. C. & Miranda, A. F. Expl Cell Res. 91, 47–56 (1975).

    Article  CAS  Google Scholar 

  6. Tannenbaum, J., Tanenbaum, S. W. & Godman, G. C. J. Cell Physiol. 91, 225–238 (1977).

    Article  CAS  Google Scholar 

  7. Ball, J. K., McCarter, J. A. & Sunderland, S. M. Virology 56, 268–284 (1973).

    Article  CAS  Google Scholar 

  8. Sundqvist, K. G. & Ehrnst, A. Nature 264, 226–231 (1976).

    Article  ADS  CAS  Google Scholar 

  9. Toh, B. H. & Hard, G. C. Nature 269, 695–697 (1977).

    Article  ADS  CAS  Google Scholar 

  10. Gabbiani, G., Chaponnier, C., Zumbe, A. & Vassalli, P. Nature 269, 697–698 (1977).

    Article  ADS  CAS  Google Scholar 

  11. Koch, G. L. E. & Smith, M. J. Nature 273, 274–278 (1978).

    Article  ADS  CAS  Google Scholar 

  12. Flanagan, J. & Koch, G. L. E. Nature 273, 278–281 (1978).

    Article  ADS  CAS  Google Scholar 

  13. Wang, E., Wolf, B. A., Lamb, R. A., Chappin, P. W. & Goldberg, A. R. in Cell Motility (eds Goldman, R., Pallard, T. & Rosenbaum, J.) 589–600 (Cold Spring Harbor Press, 1976).

    Google Scholar 

  14. Damsky, C. H., Sheffield, J. B., Tuszynski, G. P. & Warren, L. J. Cell Biol. 75, 593–605 (1977).

    Article  CAS  Google Scholar 

  15. Mousa, G. Y. & Trevithick, J. R. Devl. Biol. 60, 14–25 (1977).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1

    G. Y. MOUSA & J. R. TREVITHICK

  2. Cancer Research Laboratory, University of Western Ontario, London, Ontario, Canada, N6A 5B7

    J. BECHBERGER & D. G. BLAIR

Authors
  1. G. Y. MOUSA
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  2. J. R. TREVITHICK
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  3. J. BECHBERGER
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  4. D. G. BLAIR
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MOUSA, G., TREVITHICK, J., BECHBERGER, J. et al. Cytochalasin D induces the capping of both leukaemia viral proteins and actin in infected cells. Nature 274, 808–809 (1978). https://doi.org/10.1038/274808a0

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