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Correlation of nonsense sites in the lacI gene with specific codons in the nucleotide sequence

Nature volume 274, pages 770775 (24 August 1978) | Download Citation

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Abstract

Nonsense mutations derived from 90 different codons in the lacI gene of Escherichia coli have been correlated with the I gene nucleotide sequence. In over 80 cases the specific codon which generates the nonsense mutation can be identified. The sequence shows that 14–16 sites arise through tandem double base changes.

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Author information

Affiliations

  1. Département de Biologie Moléculaire, Université de Genève, Geneva, Switzerland

    • Jeffrey H. Miller
    •  & Christine Coulondre
  2. Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138

    • Philip J. Farabaugh

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DOI

https://doi.org/10.1038/274770a0

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