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Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study

Nature volume 274, pages 756761 (24 August 1978) | Download Citation

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Abstract

Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titres to Epstein-Barr virus structural antigens are at high risk of developing Burkitt's lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances.

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Author information

Author notes

    • G. de-Thé

    On leave at ICRF Cancer Epidemiology and Clinical Trials Unit, Oxford, UK.

    • P. M. Tukei

    Present address: Medical Research Center, PO Box 20752, Nairobi, Kenya.

    • D. P. Beri

    Dr Beri was killed in a road accident shortly after his retirement to India.

    • P. G. Smith

    Present address: ICRF Cancer Epidemiology and Clinical Trials Unit, Oxford, UK.

    • A. G. Dean

    Present address: Research Corporation of the University of Hawaii, Honolulu, Hawaii 96822.

    • G. W. Bornkamm

    Present address: Institut für Virologie im Zentrum für Hygiene, 7800 Freiburg, FRG.

Affiliations

  1. International Agency for Research on Cancer, WHO, 150 cours Albert Thomas, 69372 Lyon, France

    • G. de-Thé
    • , A. Geser
    •  & N. E. Day
  2. East African Virus Research Institute, Entebbe, Uganda

    • P. M. Tukei
  3. Kuluva Hospital, PO Box 28, Arua, and East African Virus Research Institute Field Station, Arua, Uganda

    • E. H. Williams
    • , D. P. Beri
    • , P. G. Smith
    •  & A. G. Dean
  4. Institut für Klinische Virologie, Universit Erlangen, FRG

    • G. W. Bornkamm
  5. Center for Disease Control, Atlanta, Georgia 30245

    • P. Feorino
  6. Children's Hospital of Philadelphia, 34th Street Civic Center Boulevard, Philadelphia, Pennsylvania 19104

    • W. Henle

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https://doi.org/10.1038/274756a0

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