Letter | Published:

Ethanol-induced tolerance to heat and to adriamycin

Nature volume 274, pages 699701 (17 August 1978) | Download Citation

Subjects

Abstract

HEAT can induce a transient state of thermal tolerance so that mammalian cells surviving one exposure to hyperthermia are much more resistant to a subsequent heat exposure1,2. Studies of the combined and sequential cytotoxic effects of hyperthermia and adriamycin (ADM) show that cells exposed to heat could then also develop considerable resistance to ADM3. The most reasonable explanation for the latter finding is that prolonged heat exposure modifies the cell membrane permeability to ADM. No precise mechanisms were postulated as being responsible for either type of tolerance. We report here that ethanol induces tolerance to heat and also tolerance to ADM. The qualitative patterns of cellular survival closely resemble those induced by heat exposure. These results reinforce the hypothesis that one of the prime targets of inactivation of mammalian cells by heat is the cellular membrane.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Nature 256, 500–502 (1975).

  2. 2.

    & Radiat. Res. 66, 505–518 (1976).

  3. 3.

    & J. natn. Cancer Inst. 57(5), 1063–1067 (1976).

  4. 4.

    & Proc. natn. Acad. Sci. U.S.A. (in the press).

  5. 5.

    et al. Biochim. biophys. Acta 266, 597–602 (1972).

  6. 6.

    , & Expl cell. Res. 42, 130–135 (1966).

  7. 7.

    , , & Expl cell. Res. 49, 285–292 (1968).

  8. 8.

    Cancer Res. 34, 3117–3123 (1974).

  9. 9.

    & J. exp. Med. 103, 653 (1956).

  10. 10.

    , , & Comp. Biochem. Physiol. A45, 441 (1973).

  11. 11.

    in 2nd Int. Symp. Cancer Treatment by Hyperthermia and Radiation, Strahlentherapie (in the press).

  12. 12.

    , & Cancer Res. 37, 761–764 (1977).

  13. 13.

    , & Proc. natn. Acad. Sci. U.S.A. 70, 2492 (1973).

  14. 14.

    Radial. Res. 70, 633 (1977).

  15. 15.

    & Cancer Res. 7, 1843–1851 (1978).

  16. 16.

    Expl cell. Res. 56, 382–386 (1969).

  17. 17.

    , , , & Biochim. biophys. Acta 298, 479–499 (1973).

  18. 18.

    , & Biochim. biophys. Acta 298, 500–512 (1973).

Download references

Author information

Affiliations

  1. Department of Radiology, Stanford University School of Medicine, Stanford, California 94305

    • GLORIA C. LI
    •  & GEORGE M. HAHN

Authors

  1. Search for GLORIA C. LI in:

  2. Search for GEORGE M. HAHN in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/274699a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.