Letter | Published:

Dimeric β-cyclodextrin complexes may mimic membrane diffusion transport

Nature volume 274, pages 617619 (10 August 1978) | Download Citation

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Abstract

CYCLODEXTRINS have received considerable attention as models for biological macromolecules. Much of this interest has been stimulated by their suitability for serving as relatively low molecular weight models for enzymes which catalyse various hydrolytic reactions1. Like enzymes, they form a complex with the substrate prior to the rate determining step of the reaction catalysed. We report here preliminary crystal structure analyses for isomorphous n-propanol and p-iodo-phenol complexes with β-cyclodextrin (β-CD) which we feel may provide interesting models for another aspect of biological chemistry, that of diffusion through a lipid bilayer membrane.

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References

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Author notes

    • KLAUS BARTELS

    Permanent address: Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG.

Affiliations

  1. Institut für Organische Chemie, Biochemie und Isotopenforschung der Universität Stuttgart, Pfaffenwaldring 55, D-7000 Stuttgart 80, FRG

    • JOHN J. STEZOWSKI
    • , KURT H. JOGUN
    • , EMIL ECKLE
    •  & KLAUS BARTELS

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https://doi.org/10.1038/274617a0

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