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The structure and replication of calicivirus RNA

Nature volume 274, pages 614615 (10 August 1978) | Download Citation

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Abstract

RECENT work on the structure and replication of the caliciviruses—vesicular exanthema virus (VEV), San Miguel sea lion virus and feline calicivirus—has shown some interesting and unique features. First, the morphology is unusual and differs from that of other small unenveloped RNA viruses of eukaryotes1,2. Second, the capsid structure is composed of 180 copies of a single polypeptide3,4. Third, infection of cells with caliciviruses induces the synthesis of only three polypeptides, apparently produced independently of each other5. To gain a better understanding of this unusual pattern of protein synthesis and of the replication strategy, we have examined VEV RNA and the RNA species induced in cells infected with the virus.

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Author information

Affiliations

  1. Animal Virus Research Institute, Pirbright, Surrey, UK

    • D. N. BLACK
    • , J. N. BURROUGHS
    • , T. J. R. HARRIS
    •  & F. BROWN

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https://doi.org/10.1038/274614a0

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