Letter | Published:

Internalisation of gonadotrophin–receptor complex in ovarian luteal cells

Nature volume 274, pages 598600 (10 August 1978) | Download Citation

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Abstract

IT is generally accepted that peptide and protein hormones bind to plasma membrane receptors on target cells1 and elicit their acute responses without entering the cell. The refractory or desensitised state induced by various hormones in target tissues has been shown to be mediated at least in part by loss of specific receptor sites from the plasma membrane2–7. Evidence that certain protein hormones can enter target cells8–10 led us to the present investigation which provides evidence that gonadotrophin-induced receptor loss may occur by a process of internalisation of the hormone–receptor complex following the initial interaction of gonadotrophin with the cell surface.

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Affiliations

  1. Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014

    • P. MICHAEL CONN
    • , MARCO CONTI
    • , JAMES P. HARWOOD
    • , MARIA L. DUFAU
    •  & KEVIN J. CATT

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https://doi.org/10.1038/274598a0

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