Letter | Published:

Slow relaxations of acetylcholine-induced potassium currents in Aplysia neurones

Nature volume 274, pages 494497 (03 August 1978) | Download Citation

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Abstract

RECENT studies of the vertebrate endplate have shown that similar evaluations of the lifetime of the channels opened by acetylcholine (ACh) can be obtained by four different methods1: from the decay of the endplate current2; from the ACh noise spectrum3,4; from voltage-jump-induced relaxations5,6; and from single-channel recordings7. Similar agreement has been found in the study of other systems8–11. We now report on exceptionally slow voltage-jump-induced relaxations which we have observed in Aplysia neurones during the study of a slow inhibitory ACh response caused by a selective increase in potassium ion permeability12. We have found that the time constant of the voltage-jump-induced relaxations is larger than that of the decay of the synaptic currents. These relaxations present several peculiar properties, most of which can be explained by a kinetic scheme derived from the Hodgkin–Huxley model of the potassium system in the squid axon13.

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  1. Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46 rue d'Ulm. 75005 Paris, France

    • A. MARTY
    •  & P. ASCHER

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https://doi.org/10.1038/274494a0

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