Letter | Published:

A vitamin A analogue inhibits radiation-induced oncogenic transformation

Nature volume 274, pages 486487 (03 August 1978) | Download Citation

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Abstract

The ability of vitamin A and its analogues (retinoids) to prevent chemically-induced tumours has been studied in various experimental systems1. We have investigated here the possibility that retinoids might also inhibit radiation-induced oncogenic transformation using a cell line of C3H mouse embryo fibroblasts grown in culture. We report a marked reduction in the transformation frequency by using one such compound, Ro-11-1430, the synthesis and structure of which has been described by Bollag2.

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Author information

Affiliations

  1. Radiological Research Laboratory, College of Physicians and Surgeons of Columbia University, New York, New York 10032

    • LEON HARISIADIS
    • , RICHARD C. MILLER
    • , ERIC J. HALL
    •  & CARMIA BOREK

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https://doi.org/10.1038/274486a0

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