Letter | Published:

T-cell lines producing antigen-specific suppressor factor

Nature volume 274, pages 477480 (03 August 1978) | Download Citation

Subjects

Abstract

THE immune system is now recognised as a network of interacting cells with some interactions augmenting, and others suppressing immune responses. Regulatory interactions are often mediated by T cells, and do not always require cell-to-cell contact between appropriate cells, but may be mediated by soluble transmitters, commonly termed ‘factors’. Both antigen-specific1–7 and nonspecific8–10 factors have been described. Biochemical characterisation of these factors is hampered by the often minute quantities required to mediate biological effects and by the multiplicity of regulatory pathways involved in immune responses. Our knowledge of these factors is derived from functional tests, often combined with serological analysis of the factors. One approach to the analysis of monoclonal cell products is the somatic cell hybridisation technique described by Milstein et al.11,12. Using this method, specific antibody-forming cells have been hybridised with myeloma cells, and have yielded clones producing specific antibody11. This antibody is particularly useful as it is monoclonal and large quantities can be obtained. Although attempts to produce T-cell hybrids have been successful13–15, the products have not been functional. However, only failures in expression of cytotoxic activity have been described13–15. We describe here one antigen-specific suppressor factor (SF)-producing line S1-41 and its products.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    J. exp. Med. 136, 737–760 (1972).

  2. 2.

    & Nature 256, 103–106 (1975).

  3. 3.

    , & in Ir Genes and Ia Antigens 517–527 (Academic, New York, 1978).

  4. 4.

    & J. exp. Med. 142, 1241–1253 (1975).

  5. 5.

    , , & J. Immun. 116, 305–309 (1976).

  6. 6.

    & Eur. J. Immun. 7, 310–314 (1977).

  7. 7.

    & Eur. J. Immun. 7, 417–420 (1977).

  8. 8.

    & Nature new Biol. 237, 15–17 (1972).

  9. 9.

    & J. exp. Med. 140, 19–37 (1974).

  10. 10.

    & Contemp. Top. Immun. 5, 91–143 (1976).

  11. 11.

    & Eur. J. Immun. 6, 511–519 (1976).

  12. 12.

    Somat. cell. Genet. 1, 397–400 (1977).

  13. 13.

    , , & Nature 267, 707–708 (1977).

  14. 14.

    , , & Eur. J. Immun. 7, 758–761 (1977).

  15. 15.

    Eur. J. Immun. 7, 743–746 (1977).

  16. 16.

    , & (in preparation).

  17. 17.

    & (in preparation).

  18. 18.

    & J. exp. Med. 147, 110–122 (1978).

  19. 19.

    & Eur. J. Immun. 6, 296–301 (1976).

  20. 20.

    & Nature new Biol. 245, 285–286 (1973).

  21. 21.

    & Scand. J. Immun. 4, 121–128 (1975).

  22. 22.

    , & Analyt. Biochem. 60, 149–152 (1974).

  23. 23.

    , , & Nature 258, 614–616 (1975).

  24. 24.

    & J. exp. Med. 145, 1169–1175 (1977).

  25. 25.

    , , & J. exp. Med. 145, 793–801 (1977).

Download references

Author information

Affiliations

  1. Imperial Cancer Research Fund, Tumour Immunology Unit, University College, Gower Street, London WC1, UK

    • SIRKKA KONTIAINEN
    • , P. C. L. BEVERLEY
    • , A. TORANO
    •  & MARC FELDMANN
  2. Clinical Research Centre, Harrow, Middlesex, UK

    • ELIZABETH SIMPSON
    • , ELAINE BOHRER
    • , W. C. FITZPATRICK
    •  & P. VOGT
  3. Department of Genetics, Stanford University, California, USA

    • L. A. HERZENBERG
  4. Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia

    • I. F. C. MCKENZIE

Authors

  1. Search for SIRKKA KONTIAINEN in:

  2. Search for ELIZABETH SIMPSON in:

  3. Search for ELAINE BOHRER in:

  4. Search for P. C. L. BEVERLEY in:

  5. Search for L. A. HERZENBERG in:

  6. Search for W. C. FITZPATRICK in:

  7. Search for P. VOGT in:

  8. Search for A. TORANO in:

  9. Search for I. F. C. MCKENZIE in:

  10. Search for MARC FELDMANN in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/274477a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.