Abstract
THE limitations of the gramicidin channel as a model for physiological channels are the apparent requirement of D-amino acids in the channel structure and the absence of a useful voltage dependence. The synthetic channel, HCO–(L-Ala–L-Ala–Gly)5–OMe, is shown here to form monovalent cation-selective channels in planar lipid bilayers where they exhibit a significant voltage dependence. The selectivity is similar to that of gramicidin; but the channel mean lifetime and voltage dependence are dramatically different, making the synthetic channel more similar to physiological channels.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Urry, D. W. Proc. natn. Acad. Sci. U.S.A. 69, 1610–1614 (1972).
Urry, D. W. in Conformation of Biological Molecules and Polymers (Jerusalem Symp. Quantum Chem. and Biochem.) 723–736 (Jerusalem, 1973).
Goodall, M. C. & Urry, D. W. Biochim. biophys. Acta Repts 291, 317–320 (1973).
Goodall, M. C. Archs Biochem. Biophys. 157, 514–579 (1973).
Urry, D. W. Ann. N. Y. Acad. Sci. 307, 3–27 (1978).
Baumann, G. & Mueller, P. J. supramolec. Struct. 2, 538–557 (1974).
Boheim, G. J. Membrane Biol. 19, 277–303 (1974).
Bradley, R. J. et al. Archs Biochem. Biophys. 178, 468–474 (1977).
Bamberg, E., Kolb, H. A. & Lauger, P. in The Structural Basis of Membrane Function, 143 (Academic, New York, 1976).
Kolb, H. A., Lauger, P. & Bamberg, E. J. Membrane Biol. 20, 133–154 (1975).
Hladky, S. B. & Haydon, D. A. Nature 225, 451–453 (1970).
Myers, V. B. & Haydon, D. A. Biochim. biophys. Acta 274, 313–321 (1972).
Urry, D. W. Int. J. Quantum Chem. Quantum biol. Symp. 4, 25–42 (1977).
Anderson, C. R. & Stevens, C. F. J. Physiol., Lond. 235, 655–691 (1973).
Stevens, C. F. in Cold Spring Harb. Symp. quant. Biol. 40, 169–173 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
URRY, D., BRADLEY, R. & OHNISHI, T. Characterisation of a synthetic, voltage-dependent, cation-selective transmembrane channel. Nature 274, 382–383 (1978). https://doi.org/10.1038/274382a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/274382a0
This article is cited by
-
Voltage-dependent channel formation by rods of helical polypeptides
The Journal of Membrane Biology (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.