Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Conservation of autosomal gene synteny groups in mouse and man

Nature volume 274, pages 160–163 (1978)Cite this article

Abstract

WHILE genes on the X chromosome have been conserved during evolution1 little is known about the degree of conservation of autosomal synteny groups for species distantly related in evolution such as mouse and man. The mouse gene map based on sexual genetics2,3 has been expanded by analysis of interspecific somatic cell hybrids segregating mouse chromosomes, so that the genetic maps of man and mouse can be compared. The available information indicates that genes located on different arms of the same human chromosome are not syntenic in the mouse, and genes which are many map units apart (25–45 cM) in the mouse are unlikely to be syntenic in man4–6. In contrast, genes that are tightly linked (less than 1 cM apart) seem to remain syntenic during evolution5. In addition, in species closely related in evolution, such as mouse and rat,7 or man and non-human primates8, several homologous genes have been assigned to chromosomes that are apparently homologous by chromosome banding. Five genes in the mouse (Eno-1, Pgd, Pgm-2, Ak-2, Gpd-1) are syntenic9–11 and their human homologues have been assigned to human chromosome 1; all but the human homologue of Gpd-1 are regionally assigned to arm 1p (refs 4 and 12). This apparent conservation of a rather large autosomal synteny group prompted us to investigate the extent of conservation of other autosomal regions. The results have provided chromosomal assignments for seven gene loci in the mouse and evidence for synteny of four pairs of gene loci on four different human and mouse autosomes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ohno, S. Nature 244, 259–262 (1973).

    Article  ADS  Google Scholar 

  2. Searle, A. G. Mouse News Lett. 56, 6–23 (1977).

    Google Scholar 

  3. Womack, J. E. Mouse News Lett. 57, 6 (1977).

    Google Scholar 

  4. Human Gene Mapping 3 (Karger, New York, 1976); Cytogenet. Cell Genet. 16, 1–452 (1976).

  5. Minna, J. D., Lalley, P. A. & Francke, U. In Vitro 12, 726–733 (1976).

    Article  CAS  Google Scholar 

  6. Searle, A. G. Cytogen. Cell Genet. 16, 430–435 (1976).

    Article  CAS  Google Scholar 

  7. Womack, J. E. & Sharp, M. Genetics 82, 665–675 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Miller, D. A. Science 198, 116–1124 (1977).

    Google Scholar 

  9. Chapman, V. M. Biochem. Genet. 13, 849–856 (1975).

    Article  CAS  Google Scholar 

  10. Lalley, P. A., Francke, U. & Minna, J. D. Proc. natn. Acad. Sci. U.S.A. 75, (1978).

  11. Hutton, J. J. & Roderick, T. H. Biochem. Genet. 4, 339–350 (1970).

    Article  CAS  Google Scholar 

  12. Fourth International Workshop on Human Gene Mapping (Karger, New York, in the press); Cytogent. Cell Genet. (in the press).

  13. Harris, H. & Hopkinson, D. A. Handbook of Enzyme Electrophoresis in Human Genetics (Elsevier, New York, 1976).

    Google Scholar 

  14. Rodgers, P. A., Fisher, R. A. & Harris, H. Biochem. Genet. 13, 857–866 (1975).

    Article  Google Scholar 

  15. Francke, U., Lalley, P. A., Moss, W., Ivey, J. & Minna, J. D. Cytogenet. Cell Genet. 19, 57–84 (1977).

    Article  CAS  Google Scholar 

  16. Nichols, E. A., Chapman, V. M. & Ruddle, F. H. Biochem. Genet. 8, 43–53 (1973).

    Article  Google Scholar 

  17. Chapman, V. M., Ruddle, F. H. & Roderick, T. H. Biochem. Genet. 5, 101–110 (1970).

    Article  Google Scholar 

  18. Minna, J. D. et al. Somat. Cell Genet. 4, 241–252 (1978).

    Article  CAS  Google Scholar 

  19. Kozak, C., Nichols, E. & Ruddle, F. H. Somat. Cell Genet. 1, 371–382 (1975).

    Article  CAS  Google Scholar 

  20. Nichols, E. A. & Ruddle, F. H. Biochem. Genet. 13, 323–329 (1975).

    Article  CAS  Google Scholar 

  21. Meo, T., Douglas, T. & Rijnbeek, A. M. Science 198, 311–313 (1977).

    Article  ADS  CAS  Google Scholar 

  22. Chapman, V. M. & Shows, T. B. Nature 259, 665–667 (1976).

    Article  ADS  CAS  Google Scholar 

  23. Hilwig, I. & Gropp, A. Expl Cell Res. 75, 122–126 (1972).

    Article  CAS  Google Scholar 

  24. Francke, U., Busby, N., Shaw, D., Hansen, S. & Brown, M. Somat. Cell Genet. 2, 27–40 (1976).

    Article  CAS  Google Scholar 

  25. Nichols, E. A., Ruddle, F. H. & Petras, M. L. Biochem. Genet. 13, 551–555 (1975).

    Article  CAS  Google Scholar 

  26. Womack, J. E., Hawes, N. L., Soares, E. R. & Roderick, T. H. Biochem. Genet. 13, 519–525 (1975).

    Article  CAS  Google Scholar 

  27. Hutton, J. J. Biochem. Genet. 3, 507–515 (1969).

    Article  CAS  Google Scholar 

  28. Deisseroth, A. et al. Proc. natn. Acad. Sci. U.S.A. 75, 1456–1460 (1978).

    Article  ADS  CAS  Google Scholar 

  29. Kozak, C. A. & Ruddle, F. H. Somat. Cell Genet. 3, 121–134 (1977).

    Article  CAS  Google Scholar 

  30. McKusick, V. A. & Ruddle, F. H. Science 196, 390–405 (1977).

    Article  ADS  CAS  Google Scholar 

  31. Minna, J. D., Marshall, T. H. & Shaffer-Berman, P. V. Somat. Cell Genet. 1, 355–369 (1975).

    Article  CAS  Google Scholar 

  32. Nichols, E. A. & Ruddle, F. H. Histochem. Cytochem. 21, 1066–1081 (1973).

    Article  CAS  Google Scholar 

  33. Lalley, P. A., Rattazzi, M. C. & Shows, T. B. Proc. natn. Acad. Sci. U.S.A. 71, 1569–1573 (1973).

    Article  ADS  Google Scholar 

  34. Committee on Standardized Genetic Nomenclature for Mice, J. Hered. 54, 159–162 (1963); 63, 69–72 (1972).

  35. McKusick, V. A. Mendelian Inheritance in Man (Johns Hopkins University Press, Baltimore, 1975).

    Google Scholar 

  36. Nesbitt, M. N. & Francke, U. Chromosoma 41, 145–158 (1973).

    Article  CAS  Google Scholar 

  37. Comings, D. E. Nature 238, 455–457 (1972).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. PETER. A. LALLEY

    Present address: Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37830

Authors and Affiliations

  1. NCI - VA Medical Oncology Branch, VA Hospital, Washington, DC

    PETER. A. LALLEY & JOHN D. MINNA

  2. Division of Cancer Treatment, National Cancer Institute, Washington, DC, 20422

    PETER. A. LALLEY & JOHN D. MINNA

  3. Department of Pediatrics, University of California, San Diego, La Jolla, California, 92093

    UTA FRANCKE

Authors
  1. PETER. A. LALLEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JOHN D. MINNA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. UTA FRANCKE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LALLEY, P., MINNA, J. & FRANCKE, U. Conservation of autosomal gene synteny groups in mouse and man. Nature 274, 160–163 (1978). https://doi.org/10.1038/274160a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/274160a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing