Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Quantum jumps of conductance during formation of membrane channels at cell–cell junction

Nature volume 274, pages 133–136 (1978)Cite this article

Abstract

The cell-to-cell conductance of a nascent cell junction increases by stable quantal steps. The steps evidently reflect the opening of stable cell-to-cell channels, all alike and growing progressively in number.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Loewenstein, W. R. Ann. N. Y. Acad. Sci. 137, 441–472 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Furshpan, E. J. & Potter, D. D. Curr. Topics devl Biol. 3, 95–116 (1968).

    Article  CAS  Google Scholar 

  3. Loewenstein, W. R. & Kanno, Y. J. Cell Biol. 22, 565–586 (1964).

    Article  CAS  Google Scholar 

  4. Loewenstein, W. R. Cold Spring Harb. Symp. quant. Biol. 40, 49–63 (1975).

    Article  Google Scholar 

  5. Gilula, N. B. & Epstein, M. L. Symp. Soc. exp. Biol. 30, 257–272 (1976).

    CAS  Google Scholar 

  6. Griepp, E. B. & Revel, J. P. in Intercellular Communication (ed. De Mello, W. R.) 1–32 (Plenum, New York, 1977).

    Book  Google Scholar 

  7. Makowski, L., Caspar, D. L. D., Phillips, W. C. & Goodenough, D. A. J. Cell Biol. 74, 629–645 (1977).

    Article  CAS  Google Scholar 

  8. Ito, S., Sato, E. & Loewenstein, W. R. J. Membrane Biol. 19, 339–355 (1974).

    Article  CAS  Google Scholar 

  9. Johnson, W., Hammer, M., Sheridan, J. & Revel, J. P. Proc. natn. Acad. Sci. U.S.A. 71, 4536–4540 (1974).

    Article  ADS  CAS  Google Scholar 

  10. Simpson, I., Rose, B. & Loewenstein, W. R. Science 195, 294–296 (1977).

    Article  ADS  CAS  Google Scholar 

  11. Loewenstein, W. R., Nakas, M. & Socolar, S. J. J. gen. Physiol. 50, 1865–1891 (1967).

    Article  CAS  Google Scholar 

  12. Rose, B., Simpson, I. & Loewenstein, W. R. Nature 267, 625–627 (1977).

    Article  ADS  CAS  Google Scholar 

  13. Rose, B. & Loewenstein, W. R. J. Membrane Biol. 28, 87–119 (1976).

    Article  CAS  Google Scholar 

  14. Verveen, A. A. & Dersken, H. E. Proc. I.E.E.E. 56, 906–916 (1968).

    Google Scholar 

  15. Neher, E. & Stevens, C. F. A. Rev. Biophys. Bioengng 6, 345–381 (1977).

    Article  CAS  Google Scholar 

  16. Stevens, C. F. Nature 270, 391–396 (1977).

    Article  ADS  CAS  Google Scholar 

  17. Katz, B. & Miledi, R. J. Physiol., Lond. 224, 665–699 (1972).

    Article  CAS  Google Scholar 

  18. Neher, E. & Sakmann, B. Nature 260, 799–801 (1976).

    Article  ADS  CAS  Google Scholar 

  19. Müller, P. & Rudin, D. O. Nature 217, 713–719 (1968).

    Article  ADS  Google Scholar 

  20. Gordon, L. G. M. & Haydon, D. A. Biochim. biophys. Acta 436, 541–556 (1976).

    Article  CAS  Google Scholar 

  21. Hladky, S. B. & Haydon, D. A. Biochim. biophys. Acta 274, 294–312 (1972).

    Article  CAS  Google Scholar 

  22. Kolb, H.-A., Lauger, P. & Bamberg, E. J. Membrane Biol. 20, 133–154 (1975).

    Article  CAS  Google Scholar 

  23. Bamberg, E. et al. Fedn Proc. (in the press).

  24. Urban, B. W., Hladky, S. B. & Haydon, D. A. Fedn Proc. (in the press).

  25. Peracchia, C. & Dulhunty, A. F. J. Cell Biol. 70, 419–439 (1976).

    Article  CAS  Google Scholar 

  26. Délèze, J. & Loewenstein, W. R. J. Membrane Biol. 28, 71–86 (1976).

    Article  Google Scholar 

  27. Fein, H. I.E.E.E. Trans. Biomed. Engng 13, 211–212 (1966).

    CAS  Google Scholar 

  28. Kanno, Y., Ashman, R. F. & Loewenstein, W. R. Expl Cell Res. 39, 184–189 (1965).

    Article  CAS  Google Scholar 

  29. Socolar, S. J. J. Membrane Biol. 34, 29–34 (1977).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida, 33152

    W. R. Loewenstein, Y. Kanno & S. J. Socolar

Authors
  1. W. R. Loewenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Kanno
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. J. Socolar
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Loewenstein, W., Kanno, Y. & Socolar, S. Quantum jumps of conductance during formation of membrane channels at cell–cell junction. Nature 274, 133–136 (1978). https://doi.org/10.1038/274133a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/274133a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing