Alterations in the surface properties of cells responsive to nerve growth factor

Abstract

An initial effect of nerve growth factor on a responsive nerve cell line is to increase intracellular cyclic AMP, which in turn leads to a mobilisation of calcium ions. These events are correlated with structural changes in the plasma membrane, increased cell–substratum adhesion, and neurite outgrowth.

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References

  1. 1

    Levi-Montalcini, R. in Golgi Centennial Symposium (ed. M. Santini) 437–448 (Raven, New York, 1975).

  2. 2

    Greene, L. A. Devl Biol. 58, 96–105 (1977).

  3. 3

    Greene, L. A. & Tischler, A. S. Proc. natn. Acad. Sci. U.S.A. 73, 2424–2428 (1976).

  4. 4

    Schubert, D., Heinemann, S. & Kidokoro, Y. Proc. natn. Acad. Sci. U.S.A. 74, 2579–2583 (1977).

  5. 5

    Greene, L. A. & Rein, G. Nature 268, 351–353 (1977).

  6. 6

    Schubert, D. & Klier, F. G. Proc. natn. Acad. Sci. U.S.A. 74, 5184–5188 (1977).

  7. 7

    Mains, R. E. & Patterson, P. H. J. Cell. Biol. 59, 329–345 (1973).

  8. 8

    Johnson, M. et al. Nature 262, 308–310 (1976).

  9. 9

    Patrick, J., Heinemann, S. & Schubert, D. A. Rev. Neurosci. 1, 417–443 (1978).

  10. 10

    Schubert, D. & Whitlock, C. Proc. natn. Acad. Sci. U.S.A. 74, 4055–4058 (1977).

  11. 11

    Messer, A. Brain Res. 130, 1–12 (1977).

  12. 12

    Li, A. P., O'Neill, P., Kawashima, K. and Hsie, A. W. Archs Biochem. Biophys. 182, 181–187 (1977).

  13. 13

    Stallcup, W. J. Physiol., Lond. (submitted).

  14. 14

    Schudt, C., Gaertner, U. & Pette, D. Eur. J. Biochem. 68, 103–111 (1976).

  15. 15

    Obrink, B., Kuhlenschmidt, M. S. & Roseman, S. Proc. natn. Acad. Sci. U.S.A. 74, 1077–1081 (1977).

  16. 16

    Garrels, J. E. & Schubert, D. J. biol. Chem. (submitted).

  17. 17

    Furmanski, P., Silberman, D. J. & Lubin, M. Nature 233, 413–414 (1971).

  18. 18

    Schubert, D. Neurobiology 4, 376–387 (1974).

  19. 19

    Shields, R. & Pollock, K. Cell 3, 31–38 (1974).

  20. 20

    Gingle, A. R. Devl Biol. 58, 394–401 (1977).

  21. 21

    Rasmussen, H. & Goodman, D. Physiol. Rev. 57, 421–516 (1977).

  22. 22

    Anderson, D. R., Davis, J. L. & Carraway, K. L. J. Biochem. 252, 6617–6623 (1977).

  23. 23

    Eisen, H., Nasi, S., Georgopoulos, C. P., Arndt-Jovin, D. & Ostertag, W. Cell 10, 689–695 (1977).

  24. 24

    Levi-Montalcini, R. Progress in Brain Res. Vol. 45, (eds Corner, M. A. & Swaab, D. F.) 235–258 (Elsevier, Amsterdam, 1976).

  25. 25

    Letourneau, P. C. Devl Biol. 44, 92–101 (1975).

  26. 26

    Campenot, R. Proc. natn. Acad. Sci. U.S.A. 74, 4516–4519 (1977).

  27. 27

    Palfrey, C., Kimhi, Y. & Littenhauer, U. Z. Biochem. biophys. Res. Commun. 76, 937–945 (1977).

  28. 28

    Tabuse, Y., Furusawa, M., Eisen, H. & Shibata, K. Expl Cell Res. 108, 41–45 (1977).

  29. 29

    Lyman, G. D., Preisler, H. D. & Paphadjbpoulous, D. Nature 262, 360–363 (1976).

  30. 30

    McFarlane, A. S. Nature 182, 53 (1958).

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Schubert, D., LaCorbiere, M., Whitlock, C. et al. Alterations in the surface properties of cells responsive to nerve growth factor. Nature 273, 718–723 (1978). https://doi.org/10.1038/273718a0

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