Abstract
An initial effect of nerve growth factor on a responsive nerve cell line is to increase intracellular cyclic AMP, which in turn leads to a mobilisation of calcium ions. These events are correlated with structural changes in the plasma membrane, increased cell–substratum adhesion, and neurite outgrowth.
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Schubert, D., LaCorbiere, M., Whitlock, C. et al. Alterations in the surface properties of cells responsive to nerve growth factor. Nature 273, 718–723 (1978). https://doi.org/10.1038/273718a0
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DOI: https://doi.org/10.1038/273718a0
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