Abstract
WHEN oestradiol is administered for the first time to male Xenopus the primary response is characterised by a latent period of 12–24 h before vitellogenin synthesis by the liver, or its secretion into the blood, is detected1,2. The response reaches a maximum at 10–40 d then slowly declines until by 35–40 d the liver has ceased to produce the protein. A second injection at this stage (induction of secondary response) causes a rapid re-acquisition of vitellogenin synthesis with a much reduced lag period (3–12 h), with maximum levels of vitellogenin synthesis being reached much earlier1,3,4. No satisfactory explanation has yet been found for this difference in lag periods, especially as RNA synthesis is known to be stimulated with little delay (2 h), even during primary induction5,6. We therefore asked the question of whether the drastic reduction in the lag period could be due to differential rates of utilisation of vitellogenin mRNA induced by the hormones.
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FARMER, S., HENSHAW, E., BERRIDGE, M. et al. Translation of Xenopus vitellogenin mRNA during primary and secondary induction. Nature 273, 401–403 (1978). https://doi.org/10.1038/273401a0
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DOI: https://doi.org/10.1038/273401a0
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