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Sex difference in Lewis rats in the incidence of recurrent experimental allergic encephalomyelitis

Naturevolume 272pages824825 (1978) | Download Citation



EXPERIMENTAL allergic encephalomyelitis (EAE) can readily be produced in several animal species by the injection of central nervous system (CNS) tissue or the basic protein of CNS myelin with or without adjuvants1. Although EAE is usually a nonrecurring and self-limiting process, recurrent EAE has been reported to occur spontaneously in rats2 and guinea pigs3 and also in specific conditions in the rat4. Investigations on rats have previously used female rats2,4. I report here a striking difference between male and female Lewis rats in the incidence of spontaneous recurrent EAE.

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  1. 1

    Kies, M. W. & Alvord, E. C. Jr in Allergic Encephalomyelitis (eds M. W. Kies & E. C. Alvord, Jr), 239 (Charles C. Thomas, Springfield, 1959).

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    McFarlin, D. E., Blank, S. E. & Kibler, R. J. J. Immun. 113, 712–715 (1974).

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    Wisniewski, H. M. & Keith, A. B. Annls Neurol. 1, 144–148 (1977).

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    Levine, S. & Sowinski, R. Proc. Soc. exp. Biol. Med. 149, 1032–1035 (1975).

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    Kendall, J. W. in Frontiers in Neuroendocrinology (eds Martini, L. & Ganong, W. F.) 177–207 (Academic, New York, 1971).

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    Yates, F. E. & Moran, J. W. in Handbook of Physiology, part 2, 367–404 (1974).

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    Keith, A. B. J. Neurol. Sci. (in the press).

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  1. MRC Demyelinating Diseases Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK

    • A. B. KEITH


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