Letter | Published:

Sex difference in Lewis rats in the incidence of recurrent experimental allergic encephalomyelitis

Nature volume 272, pages 824825 (27 April 1978) | Download Citation

Subjects

Abstract

EXPERIMENTAL allergic encephalomyelitis (EAE) can readily be produced in several animal species by the injection of central nervous system (CNS) tissue or the basic protein of CNS myelin with or without adjuvants1. Although EAE is usually a nonrecurring and self-limiting process, recurrent EAE has been reported to occur spontaneously in rats2 and guinea pigs3 and also in specific conditions in the rat4. Investigations on rats have previously used female rats2,4. I report here a striking difference between male and female Lewis rats in the incidence of spontaneous recurrent EAE.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & in Allergic Encephalomyelitis (eds M. W. Kies & E. C. Alvord, Jr), 239 (Charles C. Thomas, Springfield, 1959).

  2. 2.

    , & J. Immun. 113, 712–715 (1974).

  3. 3.

    & Annls Neurol. 1, 144–148 (1977).

  4. 4.

    & Proc. Soc. exp. Biol. Med. 149, 1032–1035 (1975).

  5. 5.

    in Frontiers in Neuroendocrinology (eds Martini, L. & Ganong, W. F.) 177–207 (Academic, New York, 1971).

  6. 6.

    & in Handbook of Physiology, part 2, 367–404 (1974).

  7. 7.

    J. Neurol. Sci. (in the press).

Download references

Author information

Affiliations

  1. MRC Demyelinating Diseases Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK

    • A. B. KEITH

Authors

  1. Search for A. B. KEITH in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/272824a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.