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Why do nucleic acids have 3′5′ phosphodiester bonds?

Nature volume 272, pages 798801 (27 April 1978) | Download Citation

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Abstract

Details of the stereochemistry of the 2′5′ and 3′5′ dinucleoside monophosphates of polynueleotides have been delineated in aqueous solution using nuclear magnetic resonance spectroscopy. Incorporation of these experimentally determined geometries into the structure of polynueleotides reveals that the intrinsic spatial configurations of the 2′5′ bonds cannot support helical structures whereas the geometries of 3′5′ bonds allow the formation of helical configurations for RNA.

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Author notes

    • M. M. Dhingra

    Permanent address: Tata Institute of Fundamental Research, Bombay-400005 India.

Affiliations

  1. Institute of Biomolecular Stereodynamics, State University of New York at Albany, Albany, New York 12222

    • M. M. Dhingra
    •  & Ramaswamy H. Sarma

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https://doi.org/10.1038/272798a0

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