Abstract
An antibiotic-producing organism, Streptomyces azureus, defends itself against its own toxic product by methylating the RNA of its ribosomes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dixon, P. D., Beven, J. E. & Cundliffe, E. Antimicrob. Agents Chemother. 7, 850–855 (1975).
Sopori, M. L. & Lengyel, P. Biochem. biophys. Res. Commun. 46, 238–244 (1972).
Highland, J. H., Howard, G. A. & Gordon, J. Eur. J. Biochem. 53, 313–318 (1975).
Highland, J. H., Howard, G. A., Oschsner, E., Stöffler, G., Hasenbank, R. & Gordon, J. J. biol. Chem. 250, 1141–1145 (1975).
Dixon, P. D. thesis Univ. Cambridge (1976).
Nierhaus, K. H. & Montejo, V. Proc. natn. Acad. Sci. U.S.A. 70, 1931–1935 (1973).
Nierhaus, K. H., Dohme, F. Proc. natn. Acad. Sci. U.S.A. 71, 4713–4717 (1974).
Nomura, M. & Erdmann, V. Nature 228, 744–748 (1970).
Lai, C-J., Weisblum, B., Fahnestock, S. R. & Nomura, M. J. molec. Biol. 74, 67–72 (1973).
Fahnestock, S., Erdmann, V. & Nomura, M. Biochemistry 12, 220–224 (1973).
Bodley, J. W. & Lin, L. Nature 227, 60–62 (1970).
Bodley, J. W., Lin, L. & Highland, J. H. Biochem. biophys. Res. Commun. 41, 1406–1411 (1970).
Weisblum, B. & Demohn, V. FEBS Lett. 11, 149–152 (1970).
Helser, T. L., Davies, J. E. & Dahlberg, J. E. Nature new Biol. 233, 12–14 (1971); 235, 6–9 (1972).
Lai, C-J. & Weisblum, B. Proc. natn. Acad. Sci. U.S.A. 68, 856–860 (1971).
Graham, M. Y. & Weisblum, B. Microbiology 78 253–254 (American Society for Microbiology, Washington, 1978).
Teraoka, H. & Tanaka, K. J. Bact. 120, 316–321 (1974).
Benveniste, R. & Davies, J. Proc. natn. Acad. Sci. U.S.A. 70, 2276–2280 (1973).
Pestka, S. et al. Molec. gen. Genet. 144, 235–241 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cundliffe, E. Mechanism of resistance to thiostrepton in the producing-organism Streptomyces azureus. Nature 272, 792–795 (1978). https://doi.org/10.1038/272792a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/272792a0
This article is cited by
-
Natural thiopeptides as a privileged scaffold for drug discovery and therapeutic development
Medicinal Chemistry Research (2019)
-
Avoidance of suicide in antibiotic-producing microbes
Journal of Industrial Microbiology & Biotechnology (2010)
-
Kanamycin acetyltransferase gene from kanamycin-producingStreptomyces kanamyceticus IFO 13414
Archives of Pharmacal Research (1998)
-
A nuclear mutation conferring thiostrepton resistance in Chlamydomonas reinhardtii affects a chloroplast ribosomal protein related to Escherichia coli ribosomal protein L11
Molecular and General Genetics MGG (1993)
-
Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis
Molecular and General Genetics MGG (1985)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
