Abstract
THE synthetic analogue of methionine enkephalin, FK 33-824, exerts a long-lasting and potent analgesic effect in animals after systemic and enteral administration1. In high doses it produces tolerance, cross-tolerance with morphine, and dependence in monkeys. Like β-endorphin, FK 33-824 produces akinaesia in rats and rabbits. All effects seen in animals can be abolished by naloxone. We report here on the results of the first studies performed with FK 33-824 in man (tolerance, electroencephalogram (EEG), endocrine profile and plasma levels), as a basis for future therapeutic studies.
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VON GRAFFENRIED, B., DEL POZO, E., ROUBICEK, J. et al. Effects of the synthetic enkephalin analogue FK 33-824 in man. Nature 272, 729–730 (1978). https://doi.org/10.1038/272729a0
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DOI: https://doi.org/10.1038/272729a0
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