Letter | Published:

Effects of the synthetic enkephalin analogue FK 33-824 in man

Nature volume 272, pages 729730 (20 April 1978) | Download Citation

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Abstract

THE synthetic analogue of methionine enkephalin, FK 33-824, exerts a long-lasting and potent analgesic effect in animals after systemic and enteral administration1. In high doses it produces tolerance, cross-tolerance with morphine, and dependence in monkeys. Like β-endorphin, FK 33-824 produces akinaesia in rats and rabbits. All effects seen in animals can be abolished by naloxone. We report here on the results of the first studies performed with FK 33-824 in man (tolerance, electroencephalogram (EEG), endocrine profile and plasma levels), as a basis for future therapeutic studies.

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Affiliations

  1. Department of Experimental Therapeutics, Biological and Medical Research Division, Sandoz Ltd, CH-4002 Basle, Switzerland

    • BEAT VON GRAFFENRIED
    • , EMILIO DEL POZO
    •  & JIRI ROUBICEK
  2. Psychiatric Clinic Wil, CH-9500 Wil, Switzerland

    • EVA KREBS
    •  & WALTER PÖLDINGER
  3. Medical University Clinic, D-78 Freiburg i.Br., FRG

    • PETER BURMEISTER
    •  & LOTHAR KERP

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DOI

https://doi.org/10.1038/272729a0

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