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Clones of alloreactive T cells

Naturevolume 272pages617618 (1978) | Download Citation



ONE of the basic tenets of the clonal selection theory is that antigen-specific precursor cells bear recognition structures directed towards a single antigenic specificity. The concept of clonal selection at the level of B-cell responses is widely accepted, but the proof of clonally distributed antigen receptors on T cells is lacking. Indirect evidence for clonally distributed T cell receptors has been produced in various ways (see ref. 1 for review), but functional clones of T cells have not been conclusively demonstrated. Using modifications of techniques previously described for isolation of clones of transformed cells2 and for the production of colonies of T cells in soft agar3, we have succeeded in deriving clones of alloreactive murine T cells.

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  1. 1

    Nabholz, M. & Miggiano, V. in B and T cells in Immune Recognition 261–285 (Wiley, London, 1977).

  2. 2

    Cotton, R. G. H., Secher, D. S. & Milstein, C. Eur. J. Immun. 3, 135–140 (1973).

  3. 3

    Sreidni, B., Kalechman, Y., Michlin, H. & Rozenszajn, L. A. Nature 259, 130–132 (1976).

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    Fathman, C. G., Collavo, D., Davies, S. & Nabholz, M. J. Immun. 118, 1232–1238 (1977).

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    Watanabe, T., Fathman, C. G. & Coutinho, A. Immun. Rev. 35, 3–39 (1977).

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    Pluznik, D. & Sachs, L. J. cell. comp. Physiol. 66, 319–324 (1965).

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    Fathman, C. G. & Nabholz, M. Eur. J. Immun. 7, 370–374 (1977).

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    • C. G. FATHMAN

    Present address: Department of Immunology, Mayo Clinic, Rochester, Minnesota, 55901


  1. Basel Institute for Immunology, Postfach 4005, Basel, 5, Switzerland

    • C. G. FATHMAN
    •  & H. HENGARTNER


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