Letter | Published:

Clones of alloreactive T cells

Nature volume 272, pages 617618 (13 April 1978) | Download Citation

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Abstract

ONE of the basic tenets of the clonal selection theory is that antigen-specific precursor cells bear recognition structures directed towards a single antigenic specificity. The concept of clonal selection at the level of B-cell responses is widely accepted, but the proof of clonally distributed antigen receptors on T cells is lacking. Indirect evidence for clonally distributed T cell receptors has been produced in various ways (see ref. 1 for review), but functional clones of T cells have not been conclusively demonstrated. Using modifications of techniques previously described for isolation of clones of transformed cells2 and for the production of colonies of T cells in soft agar3, we have succeeded in deriving clones of alloreactive murine T cells.

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References

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Author information

Author notes

    • C. G. FATHMAN

    Present address: Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901.

Affiliations

  1. Basel Institute for Immunology, Postfach 4005 Basel 5, Switzerland

    • C. G. FATHMAN
    •  & H. HENGARTNER

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DOI

https://doi.org/10.1038/272617a0

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