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9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

Nature volume 272, pages 583585 (13 April 1978) | Download Citation

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Abstract

Of a series of nucleoside analogues synthesized, 9-(2-hydroxy-ethoxymethyl)guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low toxicity.

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Author information

Affiliations

  1. Wellcome Research Laboratories, Burroughs Wellcome Co., Research Triangle Park, North Carolina

    • H. J. Schaeffer
    • , Lilia Beauchamp
    • , P. de Miranda
    •  & Gertrude B. Elion
  2. Wellcome Research Laboratories, Beckenham, Kent, UK

    • D. J. Bauer
    •  & P. Collins

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DOI

https://doi.org/10.1038/272583a0

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