Abstract
Of a series of nucleoside analogues synthesized, 9-(2-hydroxy-ethoxymethyl)guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low toxicity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bauer, D. J. Ann. N. Y. Acad. Sci. 130, 314–319 (1965).
Davies, W. L. et al. Science 144, 862–863 (1964).
Herrmann, E. C. Proc. Soc. exp. Biol. Med. 107, 142–145 (1961).
De Rudder, J. & Privat de Garilhe, M. Antimicrob. Ag. Chemother. 578–584 (1963).
Kaufman, H. E. & Heidelberger, C. Science 145, 585–586 (1964).
Elion, G. B., Rideout, J. L., de Miranda, P., Collins, P. & Bauer, D. J. Ann. N. Y. Acad. Sci. 255, 468–480 (1975).
Lin, T. S., Neenan, J. P., Cheng, Y. C., Prusoff, W. H. & Ward, D. C. J. med. Chem. 19, 495–498 (1976).
Witkowski, J. T., Robins, R. K., Sidwell, R. W. & Simon, L. N. J. med. Chem. 15, 1150–1154 (1972).
Schaeffer, H. J., Gurwara, S., Vince, R. & Bittner, S. J. med. Chem. 14, 367–369 (1971).
Rada, B., Blaškovič, D., Šorm, F. & Škoda, J. Experientia 16, 487 (1960).
Jones, B. R., Wise, J. B. & Patterson, A. Evaluation of Drug Effects in the Eye, 83–87 (ed.Pigott, P. V.) (Association of Medical Advisers to the Pharmaceutical Industry, London, 1968).
Corwin, M.E. et al. Invest. Ophthalmol. 2, 578–583 (1963).
Elion, G. B. et al. Proc. natn. Acad. Sci. U.S.A. 74, 5716–5720 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schaeffer, H., Beauchamp, L., de Miranda, P. et al. 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 272, 583–585 (1978). https://doi.org/10.1038/272583a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/272583a0
This article is cited by
-
Synthesis of novel seco-acyclo-N-diazolyl-thione nucleosides analogous derived from acetic acid: characterization, complex formation with ions Pb(II), Hg(II) and antibacterial activity
Journal of the Iranian Chemical Society (2022)
-
Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice
Nature Biotechnology (2021)
-
Ethyl phosphoramidates of acyclovir: design, synthesis, molecular docking (HN Protein), and evaluation of antiviral and antioxidant activities
Medicinal Chemistry Research (2017)
-
New strategies against drug resistance to herpes simplex virus
International Journal of Oral Science (2016)
-
Pharmacokinetics and Pharmacodynamics of Antibacterials, Antifungals, and Antivirals Used Most Frequently in Neonates and Infants
Clinical Pharmacokinetics (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
