Letter | Published:

Rescue of a lethal T/t locus genotype by chimaerism with normal embryos

Nature volume 272, page 539 (06 April 1978) | Download Citation

Subjects

Abstract

THE mutation THp at the T/t locus in the mouse is unique among mammalian genes because it has a sharply defined maternal effect. Like other known T/t locus dominant mutations, THp yields a short-tailed phenotype in heterozygotes of both sexes. However, THp/+ females when mated with wild type fail to give birth to short–tailed progeny; examination of embryos shows that heterozygous embryos die late in gestation with seemingly minor defects such as spina bifida and polydactyly1–3. The precise reason for death has not been determined, but must depend on some defect intrinsic to the egg, because THp/+ females successfully carry to term heterozygous embryos whose THp gene is paternally derived. I report here that lethal THp/+ maternal heterozygotes are readily rescued if they are aggregated with normal embryos, but that the germ cell defect persists, because the chimaeras fail, if female, to transmit THp to viable offspring.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Genetics 76, 795–805 (1974).

  2. 2.

    Genet. Res. Camb. 24, 207–213 (1975).

  3. 3.

    Cell 6, 441–454 (1975).

  4. 4.

    J. exp. Zool. 157, 273–292 (1964).

  5. 5.

    Mammalian Chimaeras (Cambridge University Press, London, 1976).

Download references

Author information

Affiliations

  1. Sloan-Kettering Institute for Cancer Research, New York, New York 10021

    • DOROTHEA BENNETT

Authors

  1. Search for DOROTHEA BENNETT in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/272539a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.