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Three-dimensional reconstruction of the fibres of sickle cell haemoglobin

Nature volume 272, pages 506510 (06 April 1978) | Download Citation

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Abstract

Three-dimensional reconstruction of electron micrographs of the 20-nm diameter fibres of HbS reveals an inner helical core of four strands surrounded by an outer helix of 10 strands to give a total of 14 strands. The strands are arranged with roughly hexagonal packing to produce an unusual helical structure which features a variety of intermolecular contacts and a non-circular cross section.

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Affiliations

  1. Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853

    • Gene Dykes
    • , Richard H. Crepeau
    •  & Stuart J. Edelstein

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https://doi.org/10.1038/272506a0

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