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Transmission of hormonal stimulation by cell-to-cell communication

Nature volume 272, pages 501506 (06 April 1978) | Download Citation

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Abstract

Rat ovarian granulosa cells and mouse myocardial cells respond to cell-specific hormones by cyclic AMP-dependent mechanisms. In coculture, these heterologous cells communicate by means of gap junctions. Exposure of the cocultures to a hormone specific for one cell type causes the heterologous cells to respond through a cell contact-dependent mechanism. These studies suggest that this cross-stimulation results from the intercellular communication of a mediator that is common to both cell types. The communicated mediator may be cyclic AMP.

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Affiliations

  1. Rockefeller University, New York, New York 10021

    • Theodore S. Lawrence
    • , William H. Beers
    •  & Norton B. Gilula

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https://doi.org/10.1038/272501a0

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