Abstract
Rat ovarian granulosa cells and mouse myocardial cells respond to cell-specific hormones by cyclic AMP-dependent mechanisms. In coculture, these heterologous cells communicate by means of gap junctions. Exposure of the cocultures to a hormone specific for one cell type causes the heterologous cells to respond through a cell contact-dependent mechanism. These studies suggest that this cross-stimulation results from the intercellular communication of a mediator that is common to both cell types. The communicated mediator may be cyclic AMP.
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Lawrence, T., Beers, W. & Gilula, N. Transmission of hormonal stimulation by cell-to-cell communication. Nature 272, 501–506 (1978). https://doi.org/10.1038/272501a0
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DOI: https://doi.org/10.1038/272501a0
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