Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cellular localisation of human urogastrone/epidermal growth factor

Abstract

HUMAN urogastrone (hUG) is a polypeptide prepared from urine and is chemically similar to mouse epidermal growth factor (mEGF) prepared from submandibular salivary glands. Both these substances stimulate fibroblast proliferation in tissue culture systems. hUG and mEGF inhibit gastric acid secretion in experimental animals and hUG produces an identical effect in man. We show here, using immunofluorescent techniques, that hUG is present in the duct cells of human submandibular gland and in Brunner's gland cells in the first part of the duodenum. This work suggests that these polypeptides may have a role in mucosal growth and control of gastrointestinal secretion.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Gray, J. S., Wieczorowski, X. X. & Ivy, A. C. Science 89, 489–490 (1939).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Gregory, H. Nature 257, 325–327 (1975).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Savage, C. R. J., Inogami, T. & Cohen, S. J. biol. Chem. 247, 7612–7621 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. 4

    Gregory, H., Bower, J. M. & Willshire, I. R. Proc. 11th FEBS Meet. Copenhagen (Pergamon, Oxford, in the press).

  5. 5

    Hollenberg, M. D. & Gregory, H. Life Sci. 267–274 (1976).

  6. 6

    Cohen, S. & Carpenter, G. Proc. natn. Acad. Sci. U.S.A. 72, 1317–1321 (1975).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Elder, J. B., Ganguli, P. C., Gillespie, I. E., Gerring, E. L. & Gregory, H. Gut 16, 887–893 (1975).

    CAS  Article  Google Scholar 

  8. 8

    Koffman, C. G. et al. Gastroenterology 72, 1082 (1977).

    Google Scholar 

  9. 9

    Elder, J. B., Ganguli, P. C., Gillespie, I. E., Delamore, W. I. & Gregory, H. Lancet ii, 424–427 (1975).

    Article  Google Scholar 

  10. 10

    Fitzgerald, J. D., Barret, A. M. & Gregory, H. in The Physiology of Gastric Secretion (eds Semb, L. S. & Myren, J.) 408–411 (Univeritets Forlaget, Oslo, 1968).

    Google Scholar 

  11. 11

    Turkington, R. W., Males, J. L. & Cohen, S. Cancer Res. 31, 252; 256 (1971).

    CAS  PubMed  Google Scholar 

  12. 12

    Gregory, H., Holmes, J. E. & Willshire, I. R. J. clin. End. Met. (in the press).

  13. 13

    Van Noorden, S., Heitz, P., Kasper, M. & Pearse, A. G. E. Histochemistry 52, 329–340 (1977).

    CAS  Article  Google Scholar 

  14. 14

    Kosaka, T. & Lim, R. K. S. Chinese J. Physiol. 4, 213–220 (1930).

    CAS  Google Scholar 

  15. 15

    Gregory, R. A. Secretory Mechanisms of the Gastro-Intestinal Tract (Arnold, London, 1962).

    Google Scholar 

  16. 16

    Creamer, B., Shorter, R. G. & Bamforth, J. Gut 2, 110–118 (1961).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ELDER, J., WILLIAMS, G., LACEY, E. et al. Cellular localisation of human urogastrone/epidermal growth factor. Nature 271, 466–467 (1978). https://doi.org/10.1038/271466a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links